Scientist II - Oligonucleotide Purification

Job description

  Job facts

ROLE SUMMARY:

Purification and characterization of oligonucleotides utilizing established and published procedures, and technical and theoretical understanding. Work as part of manufacturing team to delivery high quality oligonucleotides for research and development. Job will involve working on routine and challenging purification processes, troubleshooting activities, development of new methods, and operation and maintenance of various purification and analytical instrumentation.

ESSENTIAL FUNCTIONS:

·  Purification and characterization of oligonucleotides utilizing established and published procedures, and technical and theoretical understanding. Assumes responsibility for the accuracy, quality, and timeliness of oligo purification and analysis results. Maintains lab supplies and various purification analytical instruments.
·  Sets up, maintains, and runs oligo purification instruments to make oligos according to standard protocols and current priorities. Oligos are to be purified in an efficient, timely, and cost effective manner. Prioritize, schedule, and execute oligo purification to accommodate special RUSH or repeat orders. Batches the orders in the manufacturing process when there are infrequent orders such that there is a balance between manufacturing efficiency and reasonable turnaround times.
·  Delivers completed orders and interfaces with customers for oligo orders. Processes and delivers outsourced oligo orders. Works with supervisor to prioritize and triage the orders for in-house manufacturing or for approved external oligo vendor.
·  Manufacturing Support: Helps maintain the lab/reagent supplies in the lab to ensure that there is no manufacturing downtime. Helps keep the lab and work areas clean and safe. Perform routine analyses (HPLC, LCMS, and/or UV spectral) on oligos on as needed basis.
·  Summarizes experimental results, and reviews conclusions with supervisor/project leader.
·  Works with oligo synthesis personnel to ensure smooth hand off of oligos from DNA Synthesis to Oligo Purification.
·  Keeps supervisor informed of project status, particularly of significant findings and results in critical problem areas.
·  Performs work according to established internal safety guidelines and procedures, and as specified by appropriate external regulatory agencies (e.g., OSHA).
·  Assumes accountability for own lab notebook documentation and documentation of oligo orders made, ensuring purification records and results are recorded timely, accurately and consistently, and according to established formats
·  Participates in routine lab maintenance, lab safety, ISO, and QSR implementation. Troubleshoots issues related to instrumentation and process.
·  Documentation: Responsible for ensuring capture of lab data from instrumentation in SDMS/electronic notebook in a timely manner. Compiles and prepares data for statistical, scientific analyses, reports, or for presentations.

MINIMUM QUALIFICATIONS :

·  Bachelor's degree in Chemistry, Biochemistry, Biological/Life Sciences, or related field, or equivalent combination of education and work-experience
·  Minimum 2 - 5 years of relevant experience

·  Who we are

At Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.