Offers “Roche”

Expires soon Roche

Research Associate

  • Internship
  • Shanghai, CHINA
  • Design / Civil engineering / Industrial engineering

Job description



·  Job facts

Primary Purpose of Job
Collaborate with scientists and associates to support new drug discovery of immunology/oncology under minimal supervision by a PhD scientist.
Perform laboratory work, including but not limited to, assessing new drug target biology, screening and characterization of small molecule compounds for on-target and off-target effects, utilizing cell-free and cell based in vitro assays including using primary human immune cells.
Work with supervising scientist to design experiments, write experimental protocols, independently execute research plans, analyze all data, and report experimental data with high precision and accuracy.
Record experimental protocols and data in electronic lab notebook system in English.

Principle Roles & Responsibilities / Accountabilities

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Design and execute experiments in immunology, cancer biology, cell and molecular biology using cell lines and primary human and mouse cells with minimal guidance.

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Techniques include but not limited to immune cell isolation, cellular phenotyping, cell activation and differentiation and proliferation assessment, cytokine detection, qPCR, ELISA, Western blot, cell transfection, reporter cell line generation, molecular cloning, and generate knockout and knock-in cells in vitro using genome editing techniques.

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Under minimal supervision, independently establish and optimize in vitro biochemical and cellular assays; screen and characterize compounds using cell-free and cell-based assays including but not limited to study of drug dose response, MoA, cellular efficacy, cytotoxicity, etc.

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Work within team to study PK and PD relationship and therapeutic efficacy in relevant disease models.

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Proactively solve problems and bottleneck to move research projects (and/or new technologies) forward, and may serve as point of technical consultation in certain experimental techniques and/or operation of complex instruments.

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Other related duties as required, including but not limited to purchasing reagents and consumables, organizing and maintaining laboratory records, and ensuring laboratory safety.

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Occasionally, may need to work in a flexible schedule to meet project milestones and timelines.

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Prepare standard operational protocols and study reports in English.

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With supervising PhD scientist, interpret results and present to manager and team members, and give presentations at team meetings in English.

Qualification and Experience
Education/Qualifications

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M.S. in immunology, cell and molecular biology, pharmacology or biochemistry

Job Required Competencies

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Proficient in planning and conducting immunology/oncology and pharmacology experiments.

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Have significant level of scientific and technical expertise and experience in cell culture, flow cytometry, cellular and molecular immunology assays, epithelial and cancer biology, and pharmacology study of compounds.

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Preferably having worked in pharma, biotech or CRO for 2-3 years or longer.

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Experience working with primary immune cells is strongly encouraged.

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Experience working with cancer cells of the gut is a plus.

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Experience in imaging e.g., confocal microscopy and imaging analysis is a plus.

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Some experience in molecular biology, molecular cloning and genome editing experience is preferred.

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Ensure lab record and data accuracy and laboratory safety.

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Preparing/presenting results in team meeting in English, help scientist prepare internal documentations or presentations.

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Independent problem solving, collaboration and teamwork are required.

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Contribute to patents and publications.

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Familiar with scientific or technical literature within the scientific field and related areas.

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Able to record and present results in English.

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Title of positions (Research Associate, Senior or Principal Research Associate) matched with candidate's qualifications and years of experience.

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Multiple openings (3-4) are available.

Roche is an equal opportunity employer.
Research & Development, Research & Development > Research

·  Who we are

At Roche, 98,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer.