Acoustics Engineer

Job description

À propos

We are on a mission to make cell and gene therapies accessible and affordable for all. To that end, we have developed a new and unique way to grow mammalian cells using acoustic waves.

Whilst extremely promising to cure incurable diseases ranging from cancer to neuro-degenerative diseases, cell and gene therapies are facing major biomanufacturing limits with production costs as high as 2m$/patient.

Showing 100x increase in cell density and 50x reduction in production costs, our patented bioreactors help our partners in drug development and manufacturing unlock patient access to these promising therapies.

Being cell-agnostic and scalable, our process has significant potential across a range of high-value cell-based therapies - or in the cellular agriculture space more broadly.

Kolibri is a deeptech founded in 2021 and backed by leading deeptech investors, including SOSV and Entrepreneur First.

Descriptif du poste

As an Acoustics Engineer, you will play a critical role developing our next generation of bioreactors tailored to the production of adeno-associated virus as first step and other cell-based therapeutics in the longer term. This position entails ensuring the company remains at the forefront of innovation with respects to acoustic cell manipulation while collaborating with cross-functional teams to develop our products. Joining an early stage deeptech startup and a multidisciplinary team, you will need to show inventiveness, creativity, and an entrepreneurial mindset.

Your responsibilities will include:

·         Research and development

·         Develop, test, and implement acoustic piezoelectric apparatuses generating the acoustic waves exploited withing our bioprocesses

·         Generate, shape and characterize a large 3D standing acoustic wave, against various perturbations (fluidic, thermals, particulate etc.).

•       Work hand in hand with the mechanical and electrical team to improve the integration of acoustic transducers in our prototypes

·         Modelling and simulations

·         Fully model and document the acoustic wave propagation and stabilization in current prototypes, and improve them into future prototypes and applications, especially along the scaling of these prototypes

•       Conduct numerical simulations to assist with prototyping development

·         Experimental design

·         Plan and design in collaboration with the bioprocess team experiments to study the effects of acoustic forces on cells, plasmids and viral production

·         Analyze the results to draw meaningful conclusions about the relevance of current approaches and improve them over new prototypes

·         Troubleshoot experimental setups and optimize processes to achieve desired outcomes

·         Innovation

·         Stay updated on the latest developments and breakthroughs in the field of acoustic cell manipulation

·         Seek opportunities for innovation and propose new research directions or applications

·         Build upon the company IP strategy in collaboration with our selected firm and CTO through for example patent filings

Profil recherché

Must haves:

•       A PhD or higher education degree in acoustic signal generation and acoustic propagation, acoustophoresis, or a closely related field

•       Proven experience (minimum of 3 years) in experiment building, prototyping, implementation of acoustic hardware into lab/industrial environment

•       Strong experimental skills, data analysis proficiency and the ability to troubleshoot and adapt to evolving challenges

•       Independent and problem-solving mindset

•       Excellent communication and collaboration skills

•       A strong publication record and the ability to contribute to scientific advancements in the field

•       Interest in biotechnology/health & pharma domains

Nice to haves:

•       Proficiency in acoustic manipulation principles, including knowledge of acoustic, transducers, signal generation, processing or related technologies

•       Proven experience with acoustics transducers, signal generation and processing

•       Understanding of finite elements numerical methods for acoustic propagation and analysis

•       Experience with process control and automation

•       Experience in applying acoustic waves to microorganisms, especially to mammalian cells

Process de recrutement

· 
Send resume to gabriel@kolibrilab.com

· 
Offer presentation and mini fit interview with one Kolibri member (30')

· 
Tech assessment interview with our CTO (60') + case study

· 
Fit interviews with the cofounding team (~30’ x2)

· 
Reference calls

Informations complémentaires

·  Type de contrat : CDI
·  Date de début : 10 avril 2024
·  Lieu : Paris
·  Télétravail ponctuel autorisé
·  Salaire : 45000 / an