Offers “Sanofi”

Expires soon Sanofi

Scientist

  • Internship
  • Toronto, Canada

Job description



Position Title: Scientist

Site/Department: Toronto/BRD Downstream

Position Summary:

Sanofi Pasteur Limited is accepting applications for a Scientist to join the Downstream platform of our Bioprocess R&D (BRD) department. Reporting to the Platform leader, Downstream Bioprocess R&D, the Scientist – Downstream BRD will be responsible for the development of purification processes for the generation of clinical trials material (proteins and viruses) from microbial and animal cell culture for use as vaccines. The Scientist will interface between Research, Analytical Research and Development, and Manufacturing Technology, and is accountable to fulfill the specific scientific, technical and compliance-related roles for assigned projects as defined by the BRD Development Leadership Team. The Scientist will supervise, train, motivate and empower technical personnel to perform the experimental and processing tasks.

Key Accountabilities Will Include:

·  Responsible for specific scientific, technical and compliance aspects of assigned project, ensure that objectives are met.
·  Plan and supervise execution of product development activities (develop, improve, scale-up processes, and provide material and documentation for purified proteins or viruses) within platform for the project to ensure scientific and technical excellence.
·  Supervise, train, motivate and empower technical personnel to perform the experimental and processing tasks.
·  To ensure good scientific and technical leadership within BRD and the platform, keep abreast of the current developments in relevant scientific and technical disciplines and ensure current developments are implemented when appropriate.
·  Prepare internal and external presentations, patent filings, research manuscripts and review articles as required.
·  Manage and develop competencies of direct reports.
·  Ensure compliance of direct reports with GxP and other quality and documentation requirements, such as preparation of SOPs and BPRs.
·  Provide leadership for data input, standardized formats, database creation and management, and implementation of corporate standards. Ensure that direct reports are well-informed about current policies, new directions and training initiatives. Ensure teamwork and empowerment of all direct reports.
·  Coach and motivate staff to perform efficiently and achieve objectives on time, on budget.
·  Share information and harmonize development within BRD, and other departments such as Research, Manufacturing Technology, Industrial Operations, Quality Operations, Regulatory Affairs, Clinical/Medical as necessary.
·  Ensure good teamwork and provide high quality deliverables, such as Technical reports, development reports within agreed timeframes. Support regulatory submission by participating in preparation of regulatory submission documents (CTA, IND, CTD).
·  In depth knowledge of experimental work and data analysis.
·  Working knowledge of computer skills, scientific writing and presentations, supervisory/management/people development, communication skills, innovative thinking, and a familiarity with strategic planning, balanced judgment, risk analysis and budget process is required.
·  Works with the policies, procedures and regulations as required by the Company and under Occupational Health and Safety Act.
·  Supervises and monitors compliance with employment and health and safety legislation to ensure that employees work within the policies, procedures and regulations.

Platform Specific Accountabilities:

·  Development of purification processes for vaccine candidate supply. The process scale could arrange from 2L bioreactor scale to 200L bioreactor scale, and the purification process developed with targeted quality, yield and scalability requirement. The purification development needs to be transferable to clinical manufacturing platform for clinical trial material production. Expertise required includes various chromatography separation, buffer exchange and tangential flow filtration, centrifugation, sonication, protein stabilization during the purification process and chemical treatment as required.
·  Use of analytical methods for measuring purity, quality and process yield by assays such as protein content, SDS-PAGE, ELISA, HPLC, LAL et al. Development of appropriate in-process testing for the purification process development if needed.
·  Support for GMP manufacturing including process technology transfer, equipment selection and validation, process flows, vendor and raw materials selection, and process trouble shooting.

Required Qualifications:

·  PhD (Biochemistry, Biochemical Engineering, Microbiology, Chemistry) with 2+ years' experience, or MSc (Biochemistry, Biochemical Engineering, Microbiology, Chemistry) with 5+ years' experience, in protein purification, or vaccine development or relevant field
·  In-depth knowledge of protein purification, primary recovery processes, process analytical technology and quality by design
·  Working knowledge of microbiology, biochemistry, chemical engineering principles
·  In-depth knowledge of experimental design, execution and data analysis
·  Strong computer, scientific writing and presentations skills
·  Proven supervisory/management/people development experience is required
·  Highly organized and excellent communication, interpersonal and team leadership skills
·  Familiarity with strategic planning and budget process

Sanofi Pasteur: The world's leading vaccine company

Sanofi Pasteur, the vaccines division of Sanofi, is the largest company in the world devoted entirely to human vaccines. Our driving goal is to protect people from infectious diseases by creating safe and effective vaccines. Our company distributes more than 1 billion doses of vaccine each year, making it possible to vaccinate more than 500 million people across the globe. Sanofi Pasteur offers the broadest range of vaccines in the world, providing protection against 20 bacterial and viral diseases.

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to a ttract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants. Accommodations for persons with disabilities required during the recruitment process are available upon request.

Thank you in advance for your interest.

Only those candidates selected for interviews will be contacted.

Sanofi, Empowering Life

#GD-SP

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Make every future a success.
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