Post-doctoral Associate, Cell Science and Technology

Job description

About the job

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Job title : Post-doctoral Associate, Cell Science and Technology

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Grade/Level :

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Hiring Manager : Tiffany McLamarrah

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Location: Framingham, MA, On-site, less than 5% travel required

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Job Type: Permanent, Temporary, Full time,

Our Team:

The successful applicant will join the Cell Science and Technology team, who’s mission is to optimize Sanofi’s stable cell line Chinese Hamster Ovary (CHO) expression platform.  To accomplish this, our team routinely employs genetic engineering of cell lines, as well as advanced molecular biology techniques in support of cell line generation and characterization, with the purpose of improving production of next generation biotherapeutics.

Job Description:

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Generation of CHO cell lines stably expressing candidate biotherapeutics via random integration, transposase mediated integration, or recombinase mediated integration of transgenes

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Perform genetic and phenotypic characterization of CHO cell lines, including transgene copy number and transcript analysis, cell growth, and protein production

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Execute various molecular techniques for assembly of expression vectors, including Gibson assembly, PCR, restriction endonuclease digestions, DNA plasmid preparations, etc.

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Use of basic sequence analysis tools (BLAST, Geneious, etc.) to analyze vector and genomic nucleotide sequences

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Prepare reports, presentations, and publications to effectively communicate plans, progress, and results.

About you

Basic Qualifications:

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PhD +0-3 years of postdoctoral training

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All candidates must have permanent US work authorization. No visa sponsorship will be provided

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Experience with mammalian cell culture techniques, cell line engineering, and molecular biology

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Technical skills: aseptic technique, cell counting, passaging, cryopreservation, transfection, Gibson assembly, PCR, DNA/RNA isolation, ddPCR

Preferred Qualification:

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Experience with bioinformatics and data analysis – analysis of RNAseq and next gen sequencing data (short and long read data)

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Previous first-author publication(s) in internationally recognized journals

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Ability to meet aggressive timelines and deliverables in a collaborative environment

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Excellent speaking, reading and writing skills

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Strong analytical and organizational skills

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Curiosity and willingness to work independently

Pursue progress, discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

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Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.