Roche Postdoctoral Fellowship (RPF) in Targeted Protein Degradation (Oncology focus)

Job description

  Job facts

As postdoctoral fellow located at the Roche Innovation Center Basel, Switzerland, you will be driving a project in the discovery and translational area (DTA) of Oncology at the department of Molecular Targeted Therapy (MTT) in collaboration with the Large Molecule Research (LMR) department at the Roche Innovation Center Munich, Germany. The aim of this project is to investigate in depth the effect of Targeted Protein Degradation on protein expression and antigen presentation in specific cell types and explore possibilities of immunotherapeutic intervention. The studies will be focused on oncology-relevant targets and will require deep integration and collaboration with proteomics, bioinformatics, medicinal chemistry colleagues as well as protein engineers. You will exploit potential novel immuno-oncological approaches to target malignant cells in collaboration with Large Molecule Research (LMR) colleagues. Additionally, you will:

·  Plan, perform, and interpret experiments independently to drive the project efficiently
·  Develop and optimize methods to test “degrader” molecules in the cellular context
·  Lead through proteomic and mass spectrometry-based methods screening efforts
·  Collaborate closely with colleagues inside and outside the DTA and in particular with Bioinformatics, Proteomics and Medicinal Chemistry colleagues for data mining and screening deconvolution
·  Generate and interrogate cell-based models on mechanisms of resistance
·  Write procedures, reports, publications and other documents
·  Present experimental design and results internally and externally

This position is sponsored by the Roche Postdoctoral Fellowship Program and is initially limited to two years; a third year prolongation is possible.

·  Who we are

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more .

Roche is an equal opportunity employer.

Desired profile

Who you are

You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

You are proactive, creative and detail-oriented and have a passion for science. You are a team player, and are also able to work and develop your project independently. You hold a PhD or MD-PhD degree in Cancer Biology/Chemical Biology and have a strong background in Proteomics with hands-on expertise in Mass Spectrometry and data interpretation. Additionally, you bring the following skills and expertise:

·  Extensive hands-on experience with standard molecular biology methods including siRNA, shRNA, CRISPR/Cas9
·  Experience with basic assays to test oncology-relevant therapeutics would be a plus
·  Proven ability to present and publish research data, your qualification should be demonstrated by at least one first author paper in a high-quality journal during your PhD
·  Innovative spirit with high degree of scientific engagement and desire to explore novel scientific and/or technical areas
·  Ability to work in a high-pace and dynamic scientific environment
·  Excellent organizational and analytical skills
·  Excellent inter-personal and communication skills / ability to build good working relations

Please note, candidates with more than 4 years after completing their PhD can not be considered for this programme.

·