PhD studentship in Toxicology & Bioinformatics (3 years)

Job description

  Job facts

The mission of pre-clinical safety evaluations in drug development is to identify any potential side-effect liabilities of new drug-candidates and evaluate their potential translatability to the patient population.

As a PhD student in the group of Project Leaders and Modelling & Simulation you will work within a EU-funded research project which aims to develop an innovative infrastructure connecting pre-clinical & clinical data (translational safety database). You will do your PhD thesis in the scope of translational data analysis, safety biomarker and in silico modelling. Use the translational safety database in order to develop novel read-across techniques to predict effects on the basis of chemical and biological similarity.

Develop a flexible machine-learning framework, allowing for the optimal exploitation of chemical and biological information.

·  Establish assessment of new compounds in terms of potential human safety based on translational similarity approaches, integrating omics profiles
·  Develop approaches to assess the inter-species translational applicability of predictive models developed from preclinical data (animal and in vitro assays), with the aim to score their clinical relevance
·  Develop Use Cases that act as archetypes to drive development and evaluation of the envisaged tools, and allow expansion of the current knowledge about translational safety approaches
·  Get experience to work in a multifunctional consortium consisting of big pharmaceutical companies, SMEs and universities
·  Gain insight into various aspects of modern drug discovery and development

·  Who we are

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more .

Roche is an equal opportunity employer.

Desired profile

Who you are

You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

You are a motivated and autonomous person with a Master degree in the area of bioinformatics or related fields like biology, pharmacology, toxicology, biochemistry with a strong scientific curiosity and sound data analyzing skills. You feel confident in preparing (English) scientific summaries, publications and presentations.

·  General knowledge on bioinformatics and pharmacology
·  General understanding of biological and chemical principles as well as pathological effects
·  Experiences in electronic literature searches, handling of large data-sets in electronic databases and their graphical display is of advantage
·  Strong team player, but also ability to work independently
·  Good command of English (written and spoken)

The start date of the PhD position is upon availability.

Applications need to include a CV including references and a motivational letter.

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