PhD internship in the Bioinformatics and Exploratory Data Analysis group: Assessment and design of human promoter sequences (6 months)

Job description

·  Job facts

At Roche, we believe it is urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients' lives. We are brave in both decision and action; we believe that good business means a better world.

Who we are

BEDA is a research group that employs and develops computational tools to analyze biological data. These activities support the identification of new drug targets and biomarkers as well as the validation of existing drug targets. Emphasis is on using cutting edge techniques such as gene or protein expression profiling analysis methods and implementing them successfully within project teams.

As a PhD student in the Bioinformatics and Exploratory Data Analysis group (BEDA), located in Basel, you will work in close collaboration with scientists in Roche Pharma Research and Early Development (pRED) using state-of-the-art bioinformatics and biostatistics tools and methods. The main focus of this internship is to establish and apply computational approaches to understanding and optimization of human core promoter sequences.

Your tasks will include:

Literature review of recently established methods to calculate and interpret “binding landscapes” of human promoters Identification of existing in-house and publicly available datasets on transcription factor binding preferences Mining of large-scale data sets such as FANTOM5 to establish relationships between promoters, enhancers, and target genes Interpretation and prediction of mutations within human promoter regions

Who we are

Bei Roche leisten 98,000 Menschen in 100 Ländern Pionierarbeit im Gesundheitswesen. Gemeinsam haben wir uns zu einem weltweit führenden, forschungsorientierten Healthcare-Konzern entwickelt. Unser Erfolg baut auf Innovation, Neugier und Vielfalt.

Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.

Desired profile

Who you are

You are a person who wants to influence your own development. You are looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point. You are Enrolled in a PhD or medical degree program at a university and are looking to expand your experience with an industry internship (must still be enrolled at university for at least 50% of the duration of the stay at Roche).

You have a background and rich experience in bioinformatics, mathematics or a related field.

You are enthusiastic about implementing new concepts in computational biology in the form of modular, well-designed and well-documented software.

Furthermore, you have:

·  Working knowledge of bioinformatics methods
·  A strong interest in Machine Learning approaches in biology
·  Basic understanding of eukaryotic transcription regulation
·  Strong knowledge of Python or C
·  Good communication skills in English

Application needs to include a CV, two references and a motivation letter.

If you still have questions then please check our FAQs and videos on careers.roche.ch/faq.

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a unique springboard to many other opportunities at Roche.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Tags: ROiQQ ROiLS ROiEE ROiTEC RiSEDiSc

Roche ist ein Arbeitgeber, bei dem Chancengleichheit zählt.
Berufsförderungs- & Entwicklungsprogramme, Berufsförderungs- & Entwicklungsprogramme > Praktikum

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