PhD Internship in Neuroimmunology for 12 months - RiSE (m/f/d)
Stage Basel, SWITZERLAND Personal services
Job description
The Position
Characterization of T cell infiltrates in the brain during Tau disease progression
PhD Internship / RiSE - (Neuroimmunology) (12 months)
The Position
The RiSE program (Roche Internships for Scientific Exchange) is a highly competitive student research program at Roche. It offers the most talented postgraduate PhD and medical degree students the opportunity to be fully integrated into our interdisciplinary and international industry R&D environment. As a RiSE student you will enhance your competencies, gain valuable work experience with us, and eventually become part of a world-wide network of RiSE Alumni.
The Neuroscience and Rare Diseases Discovery and Translational Area (NRD DTA) is developing medicines for a range of serious neurological diseases, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, autism, spinal muscular atrophy, and Huntington’s disease.
As RiSE student in the NRD DTA you will join our Neuroinflammation laboratory in the Neuroimmunology Section, at the Roche Innovation Center Basel, Switzerland. We are a multidisciplinary team focusing on mechanisms involved in the development, progression and pathogenesis of inflammatory diseases of the central nervous system. In your role you will test the hypothesis that T cells can infiltrate the CNS during Tau disease progression and accumulate at sites of tau aggregation and neurodegeneration. Combining immunostaining approaches and multiOmics approaches, you will evaluate whether T cells infiltrates precede and/or follow
progression of pathological Tau in the brain.
You will be hosted and mentored by a Roche scientist who will guide you through your research and provide you with the needed work infrastructure and collaborative network.
During the internship your tasks will include:
Working closely with scientists and associates of the Neuroinflammation and Adaptive Neuroimmunology laboratories
Immunostaining and performing whole brain section scanning and quantification of immunofluorescence signals corresponding to pathological tau, microglia and and T-cell infiltrates
Using multiOmics approaches including single nuclei preparation from frozen brain tissues, library generation, spatial validation using RNAscope and data analysis
Presenting results and progress in internal meetings and contribute to publications
Who You Are
You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
Moreover you are/have:
Enrolled in a PhD or medical degree program at a university and are looking to expand your experience with an industry internship
In depth knowledge of adaptive immunology, neuroscience and cell biology with interest in the development and pathogenesis of neuroinflammatory diseases
Experience in tissue processing, immunofluorescence and brain tissue imaging required. Knowledge in human and rodent brain anatomy would be critical.
Experience in analyzing multiOmics data including transcriptome-based analysis.
A self-motivated and independent thinker with excellent communication skills, attention to detail, and the desire to work in a fast-paced, cutting-edge environment
Fluent in English (writing and speaking)
#RiSE
Who we are
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.
Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.
We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.
Roche is an Equal Opportunity Employer.