Intern - Early Clinical Development - Clinical Imaging

Job description

  Job facts

Within this intern role, you will be supporting the Clinical Imaging Group (CIG) within Genentech Research and Early Development (gRED) Early Clinical Development (ECD). CIG provides imaging expertise and oversight to early development clinical trial programs that support the overall development strategies of the gRED portfolio.

Machine/deep learning (DL) and radiomics image-derived metrics are tools that, if adequately validated, may be used for patient selection, stratification and early response assessment in future oncology clinical trials. The objectives of this project are to apply DL and radiomics to improve 3D lesion segmentation, identify 'features' at baseline or changes over time that are predictive of clinical outcomes such as progression-free survival and overall survival, and to explore DL or other approaches to whole-body lesion detection, in order to automatically locate known/labeled metastases throughout the body. CT and FDG-PET image datasets from trials in non small cell lung cancer patients and MRI datasets from neoadjuvant trials in early breast cancer patients may be used for training, testing, and validation of DL models, and may be augmented with other available image datasets external to gRED.

You may be required to do the following tasks:

·  Create and curate databases of CT, FDG-PET, and/or MRI measurements along with clinical and imaging parameters
·  Develop software (e.g., using R) for the extraction of information from clinical databases, or for the manipulation of imaging files (e.g., DICOM format)
·  Work with convolutional neural network toolboxes, utilize pre-trained models, and create new training models
·  Perform exploratory data analysis
·  Develop software to perform statistical modeling approaches for response assessment
·  Draft technical documents detailing processing steps
·  Collaborate and gain experience interacting with internal experts in clinical development and imaging
·  Develop a poster or presentation of your results and present at internal imaging groups and broader gRED forums

·  Who we are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at .
EEO is the Law

PAY TRANSPARENCY NONDISCRIMINATION PROVISION
The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor's legal duty to furnish information. 41 CFR 60-1.35(c)

Desired profile

Who you are

In hiring new employees, we look for people who are also inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture. Because we know that employees are critical to our success in bringing novel medicines to patients, we are dedicated to remaining a great place to work and to providing employees with programs, services and benefits that allow them to bring the best to the business and to their personal lives.

To be successful in this role, you will be or you will have:

·  BS degree (MS or PhD degree preferred)
·  Excellent computer skills; experience using R, Matlab, Python, FSL or similar programming languages
·  Familiarity with machine learning and deep learning networks (e.g. TensorFlow) and/or radiomics approaches
·  Basic familiarity with statistical analysis methods
·  Excellent communication skills
·  The ability to collaborate effectively with internal and external (academic) experts
·  The ability to work independently and proactively in a sustainable fashion with minimal guidance

The statements made in the job description are intended to describe the general nature and level of work being performed by people assigned to this job. These statements are not intended to be an exhaustive list of all responsibilities, duties and skills required of people assigned to this job.

Along with your CV/resume, please provide a cover letter with the reasons why you would like to be an intern in gRED CIG.
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