UCB is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. UCB integrates expertise in large, antibody-based molecules and small, chemically-derived molecules. UCB strategy aims at delivering innovative small and large molecule solutions to specialists for severe diseases in its chosen therapeutic areas. Already the leader in epilepsy, UCB is committed to providing novel solutions for people with severe conditions such as Parkinson’s disease, rheumatoid arthritis, and restless legs syndrome.
With 9000 people in approximately 40 countries, the company generated revenue of € 3.4 billion in 2012. The mother Company (UCB SA) and headquarters are located in Belgium Brussels, serving as coordination and governance body for the R&D, production and sales activities of UCB SA and all its affiliates worldwide.
UCB networks with leading global academic and industrial partners ensure access to novel technologies, targets and collaborative services.
Poste et missions:
The position is laboratory based and will involve experimentation with bench-scale reactors (2-5L), 20L & 200L stainless steel fermenters and associated disk stack centrifugation and pilot scale equipment. The candidate will apply Quality by Design (QbD) principles utilizing Design of Experiment (DoE) methodology and be responsible for some planning of activities, analyzing laboratory data and reporting back to project leader/line manager and team members on a regular basis. The candidate will produce accurate, traceable records of work, generating documentation for experimental reports to support technology transfer and regulatory filings (Development and Technical Report writing in English).
The candidate will undertake a range of analytical biochemistry techniques in order to understand the impact of fermentation and primary recovery parameters on process performance, biology of the cells, impact on downstream processing and product quality attributes. Where required, the candidate will work closely with in-process analytical colleagues and participate in method troubleshooting and method development. The candidate will also be expected to contribute to scientific development and technology development projects requiring innovative research, in order to improve USP and primary recovery processes and understanding.
The candidate will work in a team environment, collaborating with various process scientists (upstream and downstream) and analytical scientists. The successful candidate will utilize knowledge in biochemical engineering, chemical engineering, statistics, molecular biology, analytical methods and cellular metabolism to aid in process development and optimization of early and late stage projects, process troubleshooting investigations, characterization, evaluation of cellular responses to process operations, assessment of effects on product quality, and determination of process scalability.