Investigator - Biotherapeutics Engineering and Expression

Job description

Job Description

Biologics represent an important part of the Novartis Institutes for Biomedical Research (NIBR) therapeutic portfolio and are a critical component for intervention in the treatment of a broad range of malignancies.

The NIBR Biologics Center (NBC) builds the biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy based therapeutics.

We are seeking a highly motivated scientist specialized in protein engineering and expression of biotherapeutics to join the Scaffolds & Developability group within NBC in Cambridge, Massachusetts. Through innovative and rational protein design, the Scaffolds group works collaboratively with Disease and Platform groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations. The group supports a diverse portfolio of modalities with an emphasis on bi- and multi-specific antibodies and CAR-T.

The individual will help to lead a small dynamic team responsible for a executing a variety of experiments to design, improve, produce and characterize recombinant novel biologics modalities. The candidate will be responsible for building and supporting a medium throughput platform for the production of multispecifics modalities to support early target discovery and profiling of therapeutic leads in collaboration with groups within NBC and partners. Expertise in protein engineering (rational design, libraries) to improve the stability and developability of novel scaffolds is critical.
Posting Title

Investigator - Biotherapeutics Engineering and Expression

Desired profile

Minimum requirements

• PhD with 3-5 years or BS/MS with minimum of 10 yrs relevant experience in the expression and engineering of proteins.
• Demonstrated experience with protein expression in a breath of transient and stable expression systems and in protein purification with a variety of techniques (affinity capture, IEX, HIC, SEC).
• Experience with analytical & biophysical characterization of proteins is critical.
• Expertise in automation for DNA and protein purification is highly preferred.
• Experience in protein design of multispecific antibodies would be a plus.
• Good communication skills, creativity and the ability to multitask in a fast-paced environment are essential.
Job Type

Full Time
Country

USA
Work Location

Cambridge, MA
Functional Area

Research & Development
Division

NIBR
Business Unit

Biotherapeutic and Analytical Technologies - NIBR
Employment Type

Regular
Company/Legal Entity

NIBRI
EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.