Description de l'offre
We are looking for an investigator to join a team focusing on quantitative chemical proteomics and other affinity proteomics strategies for identification and characterization of novel drug target/ligand pairs. The successful candidate will lead efforts to design and implement small molecule affinity-based enrichment strategies utilizing a diversity of cell and tissue sources and using mass spectrometry-based quantitative proteomics as a read-out. The position offers considerable opportunities to impact all aspects towards target and ligand identification and understanding compound mechanism of action, including probe design, biochemical and biophysical characterization of protein-ligand interactions and proteomics-based investigation of cellular responses to compounds treatment. The individual will be a critical member of multi-disciplinary project teams focusing on early stage drug discovery that include chemists, cell biologists, biophysicists and data scientists.
Chemical Biology and Proteomics Investigator
Candidates should have a Ph.D. in Chemistry, Biochemistry or Biological Science with at least 3 years of post-graduate research experience. The ideal candidate would have a background in chemical biology and/or proteomics and experience in identification and in vivo/in vitro characterization of target/ligand pairs. A strong knowledge of the concepts governing binding affinity, kinetics, and selectivity as well as practical experience in affinity enrichment of proteins and peptides from cultured cells and tissues is required. Hands-on experience in nanoLC-MS/MS instrumentation, quantitative proteomics approaches (e.g. iTRAQ/TMT, SILAC) and proteomics data analysis is highly desired.
The individual should have a track record of managing and mentoring colleagues in multidisciplinary teams, strong communication skills as well as the ability to be a self-starter and thrive in a multitasking environment
Research & Development
CBT - NIBR
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.