Description de l'offre
The Biological Chemistry (BC) group is an early stage drug discovery team within Oncology research at NIBR, focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization and optimization of small molecule therapeutics. We are seeking a highly motivated, creative and collaborative scientist to join our team in a hands-on role to discover the next generation of innovative cancer treatments.
Responsibilities for the role include:
•Functional and mechanistic characterization of enzymes, substrates, and multi-protein complexes.
•Design, development, and troubleshooting of diverse biochemical and biophysical assays for use in the assessment of both mechanism and small molecule modulation of cancer targets, including hit identification, validation, and optimization.
•Analysis, interpretation, documentation, and presentation of data to the BC group and multidisciplinary project teams.
•Assessment of emerging technologies with an emphasis towards the implementation of new experimental techniques enabling drug discovery.
•Contribution to group organization, productivity, and expertise through collaboration and idea exchange.
BS/MS Biochemistry/Enzymology Research Associate Oncology
•BA/BS or MS degree in Biophysics, Biochemistry, Enzymology or a related field with some relevant laboratory experience through employment, internships, or coursework.
•An understanding of protein function, protein-ligand binding interactions, and enzyme mechanisms.
•Experience with biochemical and/or biophysical assay development for protein target and small molecule inhibitor characterizations is preferred.
•Familiarity with fluorescence-based assay techniques (e.g. HTRF, FP, DSF) and label-free technologies (e.g. SPR, ITC, LC-MS) is desired.
•An interest in implementing innovative assay technologies and developing novel assay approaches to support drug discovery programs.
•Hands-on experience with automation to enable medium throughput assays is a plus.
•Demonstrated ability to analyze, interpret, and present data in a clear manner.
•An excellent team-player with strong communication and inter-personal skills.
At NIBR we believe that along with our scientists, our culture is our greatest asset. To drive that culture each employee is expected to function in an innovative and collaborative manner. Each successful candidate will be able to demonstrate how they have functioned in this manner to drive results.
Research & Development
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.