Post Doctoral Fellow

Job description

  Job facts

The Neuroscience, Ophthalmology and Rare Diseases (NORD) Translational Area (DTA) of Roche Pharmaceutical Research & Early Development (pRED) has an opening for a postdoctoral position within the Ophthalmology department located in Basel, Switzerland. This group of Roche scientists is focused on the clinical translation of therapeutic approaches for eye diseases, including age related macular degeneration, diabetic retinopathy, and glaucoma.

We are seeking an exceptional, highly motivated, and talented scientist to perform in vivo and in vitro experiments to explore novel therapeutic targets for retinal diseases. An expertise in retinal cell biology, particularly Müller cells is preferred. In this position you will interact closely with other scientists in a laboratory that is focused on developing new therapeutics for ocular diseases. You will hold these primary responsibilities:

·  Perform ocular and non-ocular tissue dissections with subsequent sample preparation for downstream analyses (histopathology, microscopy, proteomics, RNA-seq)
·  Isolate cells from animal models of eye disease, and maintain primary cell cultures and cell lines and perform subsequent analysis (RNA-seq, TEER, Western Blot, ELISA, Luminex, qPCR, microscopy)
·  Perform optical coherence tomography (OCT) analysis of animal models of ocular disease
·  Test candidate therapeutics using in vitro and in vivo disease models
·  Communicate scientific progress through publication in scientific journals

·  Who we are

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more .

Roche is an equal opportunity employer.

Desired profile

Who you are

You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

·  You hold a PhD in biochemistry, molecular biology, vascular biology or related fields with relevant training in ophthalmology
·  Hands-on experience with animal handling and procedures
·  Familiar with ocular disease models and have experience directly performing experiments using these models
·  Have hands on experience in in vitro systems using retinal cells (Müller cell/glial cells specifically)
·  You are well organized and committed to formal record keeping, a team player, and you foster a collaborative spirit with scientist and technician colleagues. You can adapt to a fast-paced, changing environment, are fluent in English and have good presentation and communication skills
·  Independent project management and communication skills (oral, written English)

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