Associate Scientist/Scientist/Senior Scientist – Pharmacometrics and Systems Pharmacology, Clinical Pharmacology Modeling and Simulation

Job description

  Job facts

The Clinical Pharmacology Department within Development Sciences at Genentech, Inc. is seeking Ph.D. level Associate Scientist, Scientist, or Senior Scientist who is driven to use quantitative approaches to advance the clinical development of novel drug candidates. This individual will be responsible for the development and implementation of the platform and project Modeling and Simulation (M&S) strategy, in order to ensure that the right drug is administered to the right patient at the right dose and regimen. The modeling and simulation activities include population PK/PD models, translational models, PBPK, systems pharmacology models, disease models, clinical trial simulations, literature meta-analysis, and other state of the art quantitative techniques. Candidate specialized in quantitative systems pharmacology (QSP) M&S will be responsible for the development and integration of a variety of mechanistic modeling of biological systems, including models of intracellular signaling pathways, cell networks dynamics, disease models, and mechanistic PK/PD models, in the context of specific molecule or therapeutic area needs to support clinical trials such as dosing, patient selection, biomarker and diagnostic investigation, combination therapy identification and optimization.

Key technical responsibilities are to organize, execute, and report Pharmacometrics and/or Systems Pharmacology M&S independently, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences. Other responsibilities will include planning, writing, and reviewing relevant clinical documents such as study protocols, analysis plans, reports, and regulatory documents. These will be accomplished by working in close partnership with other scientists in Clinical Pharmacology, Clinical Science, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, and other functions on project teams. Qualified individual could be responsible for overseeing the strategy and implementation of Pharmacometrics and Systems Pharmacology M&S by other scientists across projects.

·  Who we are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at .
EEO is the Law

PAY TRANSPARENCY NONDISCRIMINATION PROVISION
The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor's legal duty to furnish information. 41 CFR 60-1.35(c)

Desired profile

Who you are

In hiring new employees, we look for people who are also inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture. Because we know that employees are critical to our success in bringing novel medicines to patients, we are dedicated to remaining a great place to work and to providing employees with programs, services and benefits that allow them to bring the best to the business and to their personal lives.

Multiple job opportunities are available

EDUCATION:

A Ph.D. in Pharmacometrics, Biomedical or Chemical Engineering, Biostatistics, Applied Mathematics or Physics, Pharmaceutical Sciences, or related discipline with 0+ year (for Associate Scientist), 3+ years (for Scientist), 7+ years (for Senior Scientist) of industry, regulatory, and/or related post-doctoral Modeling and Simulation experience is required.

REQUIREMENTS:
Candidates should have solid expertise in quantitative pharmacology and strong hands-on modeling and simulation skills. Demonstrated impact on drug development through quantitative approaches is highly desired. Rich hands-on experience with NONMEM, SPLUS, R, Simcyp, GastroPlus, SimBiology, and/or other modeling and simulation software is required. Experience with clinical trial simulation, optimal design, advanced mechanistic PK/PD and/or system pharmacology modeling is highly preferred. Experience in interaction with regulatory agencies is highly desired. The candidate must have excellent communication and interpersonal skills and the ability to work independently and effectively on interdepartmental project teams. The candidate must have strong leadership skills and the ability to influence. People management experiences are a plus.

*LI-PD-KM

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