Principal Scientist, Cell Line Development

Job description

Job Description The Cell Line Development (CLD) group is part of the Integrated Biologics Profiling (IBP) Unit within the BTDM organization. The main task of the group is the generation of recombinant mammalian cell lines for the production of biopharmaceuticals. This includes all steps from generating expression vectors to the establishment of high producing clonal cell lines for the preparation and timely delivery of drug substances (DS); FACS techniques and laboratory automation are used. The CLD group is currently looking for a talented Principal Scientist. In this position, the successful candidate will report to the CLD-3 Team Head and other project management functions. He/she will lead molecular biological tasks, in particular vector construction, and NGS Sequencing; act as a Functional Lead with several technicians to lead; plan and manage dedicated cell line development projects; participate in sub-teams and contribute to overall BPRD strategies and goals. A further responsibility will be the evaluation and implementation of new technologies to improve the performance of the existing expression systems as well as the interaction with external suppliers. Project management tasks will be an integral component of this position as well. Major Accountabilities: 1. Actively participate in teams, projects, networks and/or platforms as IBP representative. Fulfill all related tasks and responsibilities related to own discipline. Meet quality, quantity and timelines in all assigned projects, networks and/or platforms. 2. Design, plan, perform and monitor all assigned activities. Document and interpret results, evaluate data, draw relevant conclusions, write reports. Generate scientific and international registration documents to hand over to internal and/or external partners (TechOps, authorities, external companies). 3. Proactively communicate key issues and any other critical topics in a timely manner to the appropriate management level and/or to any other relevant project team member(s). 4. Advise team members and work according to appropriate SOP's, GLP, GMP, OQM, HSE, ISEC and Novartis guidelines. Coach/lead team members: support objectives setting, performance evaluations and development planning discussions. 5. Contribute to evaluation of new scientific technologies/equipment. 6. Support the journey towards a multi-skilled, highly innovative and motivated workforce operating in a self-directed team set-up. Support cultural evolution and change management.

Desired profile

Education: PhD in Molecular Biology, Cell Biology or Biotechnology. Language: Fluency in English is essential, German speaking is helpful. Professional Experience: - Relevant postdoctoral experience would be an asset. Industrial background is of advantage. - Excellent knowledge of laboratory and/or technical tools with a focus on molecular biology and mammalian cell culture. - Ideally, the focus of previous work has been heterologous gene expression in mammalian cells. - Proficient in utilization of special tools/equipment (lab automation tools and specialized facilities e.g., containment/sterile labs). - Advanced knowledge of software and computer tools (e.g. Vector NTI, data bases, NGS and electronic lab book documentation systems). - Very good communication skills. Good presentation skills and scientific/technical writing - Experience in people management and/or project management in a matrix organization is desirable. - The willingness to participate in multifunctional project teams is also a prerequisite. .