BS/ MS level in vivo Scientist

Job description

Job Description

The successful candidate will join a dynamic, multi-disciplinary team of scientists in the exploratory immuno-oncology group, playing a key role in the evaluation of new drug candidates in vivo and enhancing our understanding of validated targets. Ideal applicants will possess excellent communication and organizational skills, critical problem-solving abilities, and a commitment to excellence.

In particular, this position will focus on the use of in vivo models including, but not limited to, syngeneic mouse tumor models, humanized mouse models, autoimmune disease models and use of murine knockout/knockin models to better understand mechanisms of cancer immunotherapy pathways. Experience in profiling of tumor infiltrating immune cells is required.

Candidate will be responsible for:
• Performing exploratory and preclinical studies including, but not limited to, efficacy, PK and PD analysis of syngeneic tumor models.

• Profiling of tumor infiltrating immune cells, including harvesting of tumor, processing of tumor tissue and flow cytometric analysis of immune cells. Analysis of multi-color flow cytometry using FlowJo.

• Documentation, analysis and interpretation of experiments for the evaluation of pre-clinical candidates as potential therapeutic agents.

• Written and verbal presentation of results within a multidisciplinary team environment.

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Desired profile

Minimum requirements

A BS/MS level degree in one of the life sciences, with expertise in the in vivo validation of immune targeting therapies and pharmacology, with at least 2 years industry experience or equivalent in academia. Experience using flow cytometry techniques to analyze tumor immune cell infiltration is required. Industry experience with syngeneic mouse tumor models is an advantage. Knowledge of designing and executing PK/PD studies for both LMW and biologic agents is a plus. The candidate should have in-depth knowledge of immuno-oncology research, particularly related to industrial drug discovery and development, with emphasis on validation of the in vivo activity of immuno-oncology therapies. The candidate is also expected to be highly motivated, to have excellent communication and inter-personal skills.