Scientist Preparative Chromatography

Job description

‘Caring for the world, one person at a time'... inspires and unites the people of Johnson & Johnson. We embrace research and science - bringing innovative ideas, products and services to advance the health and well-being of people.
Employees of the Johnson & Johnson Family of Companies work with partners in health care to touch the lives of over a billion people every day, throughout the world.

Janssen Pharmaceutica joined the Johnson & Johnson group in 1961. Today, Janssen Pharmaceutica is one of the most innovative pharmaceutical companies in the world. Our research and development centre develops products for a wide range of disease areas, such as mental disorders, neurological problems, infectious diseases, immunological disorders, cancer, and cardiovascular and metabolic conditions.

The Janssen Preparative Separation Techniques (PST) group is a Centre of Excellence for small molecule purification within Janssen (Pharmaceutical Division of Johnson & Johnson). As a subdivision of API Small Molecule Development it has the following main tasks:

·  Purification of intermediates to support process development work.
·  GMP-purification of intermediates and final API for clinical use.
·  Purification of reference material and isolation of impurities for analytical purposes.
·  Development and optimization of chromatographic processes for production purposes.
·  Assessment, development and implementation of new separation techniques.
A key element to fulfil this role is the presence of high level scientific and technological knowhow in the group).

To help us achieve these tasks, we are looking for a (m/f):

Scientist


KEY TASKS & RESPONSIBILITIES:

·  Guide development of appropriate purification methods for small molecules from the mg to kg scale.
·  Analytical and preparative purifications of research compounds to support process development groups.
·  Execute achiral and chiral purification of pharmaceutical compounds and isolation of impurities
·  Execute small-scale studies and pilot scale purification studies.
·  Maintains lab presence and is actively involved in lab work
·  Analyze and interpret scientific results.
·  Write scientific reports and present work as needed.
·  Initiate and champion new technologies (e.g. solvent nanofiltration, biomolecule purification).
·  Identify collaboration opportunities with internal and external partners.
·  Build and maintain contacts with representatives of equipment and material suppliers.
·  Initiate and foster collaboration with external research institutes, companies and universities.
·  Keep up-to-date knowledge on purification related technologies.
·  Representation of department in cross-functional working groups.
·  Supervision of thesis and undergraduate students.
·  Carry out your work within the predefined safety, environmental and quality standards.

Desired profile

·  PhD or Master's Degree with specialization in (analytical) chemistry/ engineering or related discipline.
·  In depth knowledge and technical proficiency in preparative chromatography, HPLC and related techniques.
·  Adequate knowledge of organic chemistry
·  Experience with chemical process development, scale-up and GMP manufacturing with emphasis on chromatographic purifications.
·  Experience with SFC is an asset.
·  Experience with biomolecule purification is an asset.
·  Experience with organic solvent nanofiltration is an asset.
·  Proven problem solving capacity
·  You are practical and result-driven.
·  You are efficient, flexible and dynamic.
·  You integrate and work effectively in a multidisciplinary team.
·  You have good social and communication skills.



What's in it for you…?
“Caring for the world, one person at a time…”
As an employee we consider you as our most valuable asset. We take your career seriously.
As part of a global team in an innovative environment your development is key and our day-to-day responsibility.
Through e-university, on the job training, various projects and programs, we ensure your personal growth.
Our benefits make sure we care for you and your family now and in the future.