Scientist, Flow Cytometry Receptor Occupancy and Target Engagement Assay Development Job

Job description

Scientist, Flow Cytometry Receptor Occupancy and Target Engagement Assay Development-6445150820DescriptionJanssen Biotech, Inc.a division of Johnson & Johnson's Family of Companies is recruiting for an Scientist, located in Spring House, PA.At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.
Janssen Biotech, Inc. delivers on the promise of new treatments and ways to improve the health of individuals with serious disease. Built upon a legacy of innovative firsts, Janssen Biotech pursues advancing patient care with immunology and oncology solutions. Please visit http://www.janssenbiotech.com/ for more information.
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
This laboratory-based position is in the Receptor Occupancy and Target Engagement Assay Development group within the Biologics Clinical Pharmacology department. The group develops assays to measure the in vitro and in vivo interaction of biopharmaceutical drugs with their protein targets, both on cell surfaces and in soluble forms, in biological matrices. These assays are used to generate data from both preclinical and clinical studies to support PK/PD modeling to inform human dosing strategies. The primary focus for this position will be the development and qualification of flow cytometry assays to measure in vivo receptor occupancy of biotherapeutics to cell surface targets in whole blood and tissue samples, supporting an extensive effort in immuno-oncology pre-clinical and clinical drug development programs. Additional responsibilities may include the development of immunoassays to measure free and total forms of soluble drug targets in serum. All work will be performed in GLP-like conditions. In addition to the laboratory-based activities, the position will also require effective management of method transfers to CRO partners and the management of study bioanalysis at the CROs. The position resides in a highly interactive team, so collaborative spirit, excellent communication skills, both written and verbal, and strong interpersonal skills are both necessary and highly valued. S/he will effectively and frequently collaborate with colleagues within Biologics Clinical Pharmacology as well as the partners supported.
QualificationsPh.
D. in Immunology or a related scientific discipline with at least 1 years of experience OR a M.S. with at least 5 years of experience using flow cytometry to analyze cellular markers in blood or tissues, especially in preclinical disease models is requiredExperience in operation of various cytometers and understanding associated analysis software (B-D instruments, FlowJo, etc) are requiredExperience in development of receptor occupancy and soluble target assays is preferredExperience with ELISA, MSD and other ligand binding assay platforms is requiredPrior experience in a GLP laboratory setting is preferredThe successful candidate will have excellent record keeping and communication skills, extensive data interpretation experience and a passion for understanding biotherapeutics and target biologyThe successful candidate should be intellectually curious and well informed on the latest scientific advances in the fieldExcellent interpersonal skills with the ability to interact effectively with people, internally and externally are requiredDetail-oriented, with excellent organizational, record-keeping, oral and written communication skills are also requiredBE VITAL in your career. Be seen for the talent you bring to your work. Explore opportunities within the Johnson & Johnson Family of Companies.
J2W:BIOPrimary Location:North America-United States-Pennsylvania-Spring HouseOrganization: Janssen Research & Development, LLC. (6084)Job Function: R&DCertain sites within the Johnson & Johnson Family of Companies participate in E-Verify as appropriate in accordance with Company guidelines and federal or state law. To learn more about the government sponsored program and to see a list of the sites that are currently enrolled, please click here.
Johnson and Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law. EEO is the Law EEO is the Law GINA Supplement