Upstream Process Scientist

Job description

Your Responsibilities :
Upstream Process Scientist

Role Summary:
BioPharm Process Research (BPR) is an early process development function responsible for accelerating biopharmaceutical assets into clinical manufacture by linking drug discovery and product development. As part of this wider group the Upstream Process Research group is responsible for cell line selection, the development of bioreactor production processes and their transfer to GSK's large-scale clinical manufacturing facilities to support the progression of GSK's innovative early stage Biopharm portfolio which includes monoclonal antibodies, bispecific antibodies and recombinant proteins.

We are now looking to leverage our recent investment in automated upstream and CLD processes by embedding advanced analytical techniques and data analysis to better understand our platform processes. Enhanced data sets will enable improved process models which we will use to drive better cell line selections, increased capacity and reduce timelines.

The successful candidate will be an enthusiastic and passionate ‘hands on' scientist who will strengthen our bioreactor team by working closely with our cell line development, process analysis and downstream processing groups to progress our Onestream vision and support our End to End Biopharm capability.

Key Responsibilities include, but are not limited to:

• Develop our Onestream vision by practically linking Upstream and Downstream needs through focused experimental work packages
• Embed spectroscopic and other advanced analytics into larger scale bioreactor platforms
• Generate bioreactor data to increase the understanding of our platform processes through metabolite and spectroscopic characterisation and use this to improve our process models across scales from 15mL to 50L
• Contribute to wider automation, data analysis and bioinformatic work packages within BPR to support our End to End Biopharma Capability
• Deliver cell culture batches (up to 50L scale) to support downstream processing, analytical development and technology transfer
• Assist with authoring detailed technical reports and process transfer documents to support tech transfer activities

CLOSING DATE for applications: Friday 24th May 2019 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the ‘cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

*LI-GSK

Why You?

Basic qualifications:
• Degree (ideally post graduate) in Biochemical Engineering, Biochemistry or other Life Sciences related discipline
• Practical experience of mammalian cell culture at bench and bioreactor scale
• Hands on experience of Upstream Process unit operations up to at least 50L scale
• Effective communication skills

Preferred qualifications:
• Knowledge of, and ability to apply, experimental design and data analysis principles to derive quality results in a timely fashion
• Proven experience of evaluation and implementation of appropriate new ideas and technologies
• Ability to apply innovative solutions to process development problems
• Understanding of scale-up/scale-down and the ability to apply this to the generation of predictive process models

Why GSK? :
GSK is a science-led, global healthcare company that produces innovative medicines, vaccines and consumer healthcare products.
We are committed to overcoming some of the biggest challenges in global health; delivering products of value in a responsible, sustainable way; and providing access to medicine for the world's poorest communities.

Contact information:
You may apply for this position online by selecting the Apply now button.

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