Scientific Leader, Cheminformatics
Unidos, PHILIPPINES
Job description
Nombre del sítio: USA - Pennsylvania - Upper Providence
Fecha de publicación: Jan 17 2024
Job Purpose
· The new Research Tech Data and Predictive Sciences function is focussed on harnessing the power of GSK’s data-as-an-asset to drive research productivity upper quartile ambitions.
· As a Scientific Leader in the Cheminformatics (CIX) group, you will be focused on developing, integrating and embedding advanced computational methods and predictive in silico models that accelerate discovery of medicines.
· Data & Predictive Sciences will only be successful by working in close collaboration with Research Tech, TAs, GSK Tech, AIML, Vaccines, Risk & Compliance, and across lines within the function itself, and by developing and fostering a high-performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on enabling value realization through end-user uptake and measuring impact.
Key Accountabilities / Responsibilities:
· You will work with other D&PS team members as well as the modelling groups in other parts of Research Tech (focus on Molecular Modalities and Pre-Clinical Sciences) to develop or embed methods that are applicable to our growing modality toolbox including covalents, PROTACS and ADCs and oligos.
· You will work closely with program teams and modelling teams in Research Tech to solve drug discovery project issues using cheminformatics tools and solutions or other approaches relevant for the problem at hand (ML, Statistics, comp chem, comp bio, bioinformatics, etc.).
· Development of novel methods and solutions, contributing code & algorithms to the departments scientific infrastructure and automated modelling/design platforms.
· You will partner with the Tech organizations to facilitate the move to cloud.
· You will prepare and present results of key validation experiments, details of capability builds, and developments on active drug discovery projects to internal and external groups in a way that is both informative and accessible to the non-subject matter expert.
· You will be an opinion leader, expert resource and consultant for other members of the Data & Predictive Sciences department.
· You may define, lead and execute capability projects or project workstreams
· You will work with others within a multidisciplinary matrix team that spans different organizations to execute on joint objectives.
Why You?
Basic Qualifications:
• PhD in Computational Chemistry or Life Sciences or equivalent.
• Three or more years of pharmaceutical or biotech experience.
• Three or more years of experience in computational sciences which will include a deep knowledge of machine learning and cheminformatics and related methods such as QSAR, active learning, molecular generation, toolkit programming, PBPK modelling, etc.
Preferred Qualifications:
• A track record of impactful publications.
• Track record of leading teams, matrix groups or method development projects.
• Demonstrated track record in leading change.
· Demonstrated ability to work as team lead or member. Ability to participate and lead in a matrix environment.
· Evidence of influencing organisational scientific strategy
· Demonstrated ability to build robust statistical modelsfrom large scientific data sets.
· Track record of developing robust scientific software in languages such as C/C++, Python or Java.
· Experience with modern code development/management environments and coding standards.
· Evidence of identifying, developing, and applying innovative solutions to scientific and technological problems faced in the Life Sciences
· Deep expertise to programmatically collect, combine, mine and analyze complex biological and chemical data
· Deep expertise with chemical toolkits such as ChemAxon, OEChem or RDkit
· Deep expertise with scientific pipelining tools such as Pipeline Pilot or Knime.
· Evidence of strong critical thinking skills.
· Evidence of strong problem-solving & high learning agility
· Excellent written and oral communication skills and the ability to interact effectively with scientists in other disciplines with a positive, collegial, collaborative attitude.
· Extensive knowledge of related disciplines (medicinal chemistry, HT screening, analytical chemistry, systems biology, DMPK, Tox, Imaging) to enable multidisciplinary approaches to be identified and integrated into a cohesive project plan.
Why GSK?
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why Us?
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.
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