RNA Biology Lead

Job description

Nombre del sítio: USA - Massachusetts - Waltham
Fecha de publicación: Feb 2 2024

About the Role

We are seeking a highly motivated and experienced RNA Biology Director to join our Vaccines R&D team. The successful candidate will lead strategies to answer scientific questions pertaining to mRNA vaccines mechanism of action and performance at the molecular, biochemical, cellular and tissue level to establish structure-activity information. The candidate will act as a liaison across R&D global teams within platform and research areas groups to advance platform and vaccine programs. In close partnership with cross-functional teams, the candidate will set strategies and sponsor cutting-edge technologies to characterize existing and novel RNA vaccines modalities.

  Responsibilities

·  Lead the mechanistic profiling of RNA vaccines, related to both the early events after vaccine administration and the induction and quality of vaccine antigen-specific immunity
·  Provide scientific leadership and work cross-functionally to determine:
·  how mRNA vaccines interact with different cell populations at the site of injection and further disseminate in the body
·  how the early innate immune functions e.g., cell activation and antigen production after mRNA vaccine delivery influence the quality of the vaccine-specific responses
·  how antigens expressed by mRNA vaccines can increase vaccine-specific B cell and T cell immunity
·  new solutions to improve non-clinical screening of RNA backbones and LNPs
·  Lead a matrix team of multi-discipline experts including biology, immunology, safety assessment, computational sciences, clinical scientists, translational scientists, and others
·  Set discovery strategy, objectives and priorities that are aligned with portfolio deliverables, and ensure timely program advancement
·  Establish and/or key collaborations with internal and external partners
·  Provide strong scientific leadership in RNA biology and collaborate with key internal stakeholders, including Vaccine Development Leads (VDLs), Discovery Project Leads (DPLs), R&D Leadership teams, Regulatory, Global Patents, Legal and Business Development Leaders, and external stakeholders
·  Take a key role in preparation of internal documents and external patent applications, regulatory submissions, scientific papers, and other communications

Basic Qualifications

·  Ph.D. in immunology, RNA biology, cell biology, or a scientific field
·  5+ years of experience in RNA vaccines/therapeutics discovery at pharmaceutical or biotech industry, with working knowledge of both scientific and non-scientific aspects
·  5+ years' experience on characterization of innate and adaptive immune responses to RNA vaccines
·  5+ years' experience in RNA biology, RNA or RNA viruses innate immunity
·  2+ years' experience leading a matrix team, presenting research and strategy

Preferred Qualifications

·  Hands on experience with the development and utilization of in vitro and cell-based assays to characterize mRNA expression and innate sensing
·  Working knowledge of innate and adaptive immune responses to RNA vaccines

Why GSK?

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.​

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.​

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Our approach to R&D

Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why Us?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

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