Principal Scientist, Cell & Gene Therapy

Job description

Your Responsibilities :
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

GSK's Cell & Gene Therapy department supports an increasing portfolio of novel and effective cell and gene therapies. The team is responsible for delivering the Chemistry, Manufacturing and Controls (CMC) aspects of the projects from early phase to launch, and the development of innovative technologies to enable improvements to cell & gene therapy manufacture.
We are seeking a highly motivated and creative person to lead the viral vector Upstream Process Development team based in Stevenage. The successful candidate will use their experience in biologics and cell culture process development to drive the team to define and optimize manufacturable processes and deliver on development activities, including scale-up and technology transfer.
Managing the Upstream team, you will have the unique opportunity to enhance and improve viral vector processes in the exciting field of Cell & Gene Therapy.
Your duties will include and are not limited to:
• Lead the Upstream Vector Process Development Team to develop, optimise, and establish robust, cost-effective upstream platforms to support GSK's product portfolio
• Support the development of projects from early clinical to commercialisation by providing input to project teams, directing the development work of the vector process development team, reviewing data, supporting regulatory interactions.
• Technology transfer and establishment of upstream vector processes to manufacturing facilities.
• Work collaboratively with CGT scientific leads –Downstream Vector Process Development, Cell Line Development, Process Research, Cell Process Development, Validation Life Cycle Management, Analytical Development, Formulation Development, and Manufacturing Supply Chain to deliver platforms and projects.
• Lead, motivate and develop the Upstream Vector Process Development Team
• Define and manage delivery of upstream vector process development programmes outsourced to external development partners
• Propose, define, develop and establish innovative technologies and approaches to improve viral vector manufacturing
• Maintain awareness of novel technologies that have potential to impact vector manufacturing platforms

The successful candidate will report to the Head of Vector Process Development within CGT and will be based at GSK's Stevenage site.

Closing date: 16th July 2019

When applying for this role, please use the ‘cover letter' of the on-line application to describe how you meet the competencies required for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Thank you for your interest in this opportunity.

*LI-GSK

Why You?

Basic qualifications:
• PhD in Biochemical Engineering, Biological sciences, or related field with experience in the upstream development of cell culture-based biologics or cell therapy manufacturing processes

OR

• Bachelors or Master's degree with extensive experience in the upstream development of cell culture based biologics or cell therapy manufacturing processes

Preferred qualifications:
• Experienced in the development and optimisation viral vector, vaccine, or biologics- based manufacturing processes, including process scale-up, tech transfer, and cGMP manufacturing
• Understanding of complex multidisciplinary area of molecular biology, cell biology, transfection, vector expression, scale-up and manufacturing
• Experience in the use of statistical experimental design and data analysis
• Prior leadership/management experience of scientists
• Excellent communication and project management skills to facilitate interactions with internal groups and with external collaborators and partners
• Demonstrable ability to work effectively in multi-disciplinary and multi-cultural teams

Why GSK? :
GlaxoSmithKline (GSK) is a science-led, global healthcare company, employing over 100,000 people in more than 115 countries. Our mission is to improve the quality of human life by enabling people to do more, feel better, live longer.

Contact information:
You may apply for this position online by selecting the Apply now button.

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