Principal Scientist – Antibody Pharmacology

Job description

Your Responsibilities :
GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Biopharm Discovery is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling.

Antibody Pharmacology at GSK comprises a team of 20+ assay scientists, immunologists and biologists who conduct functional assay design, screening and characterisation of potential antibody-based drug molecules. The team is an integral part of the Biopharmaceutical Molecular Discovery organization that is responsible for the discovery of candidate biologics across several Therapeutic Areas including Immuno-oncology, Respiratory, Immuno-Inflammation and Infectious Diseases.

We are seeking an experienced laboratory scientist with a deep understanding of antibody structure and function relationships, and in particular the contribution of Fc biology to the Mechanism of Action and PK/PD of an antibody. The candidate will be expected to act as a Subject Matter Expert (SME) in Fc biology and be accountable for profiling Fc functions and selecting the most suitable Fc variant that produces the desired Fc functionality.

Depending on experience, the candidate may be responsible for leading and driving a Fc biology matrix team in designing novel in vitro assays that are disease relevant, and standardizing assays to accelerate the discovery process.

Key responsibilities:
• Demonstrate scientific leadership through acting as a Subject Matter Expert in Fc biology; Stay abreast of the latest literature and developments in the field; Be accountable for selecting the most suitable Fc variant that produces the desired Fc functionality
• Collaborate with other functions within GSK R&D, especially Antibody Technology and Translational Science; Devise and implement a Fc biology strategy that supports the discovery and development of best-in-class antibody drug candidates
• Influence Drug Discovery Project Teams as an Antibody Pharmacology SME. Accountable for designing and conducting disease relevant functional assays and Fc biology assays; Deliver timely quality data packages that enable project decision-making and progression
• When suitable, participate in relevant technology projects that optimise/modernise the antibody drug discovery process
• Be able to publish and present both internally and externally

We can offer you a collaborative learning environment and the opportunity to develop your career and gain experience across drug discovery. If you share our priorities of innovation, performance and trust and are motivated to contribute towards bringing lifesaving drugs to patients, then we'd love to hear from you.

Close date: 29th May 2019

Please use your cover letter to highlight how you meet the competencies for the role, your cover letter along with your CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

GSKBiopharm_Discovery
*LI-GSK

Why You?

Basic qualifications:
• PhD or equivalent degree in Immunology, Biology, or other relevant Life Sciences
• Preferably post graduate experience in biomedical research and with a track record of achievement in Fc biology (publications, patents, professional milestones)
• Hands-on experiences and proficient in Fc biology (ADCC, ADCP, CDC), immune cell function assays (T cell, macrophage, NK, monocyte, etc), PBMC culture, Flow cytometry, cytokine profiling, signaling pathways

Preferred qualifications:
• Deep scientific knowledge of antibody structure and function
• Drug discovery experience in Immuno-oncology, Oncology or Inflammation is desirable
• Highly motivated self-starter with demonstrated problem solving skills
• Demonstration of a high level of scientific rigor and integrity
• Effective team player with excellent people and communication skills

Why GSK? :
GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Contact information:
You may apply for this position online by selecting the Apply now button.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

jobDetails