Investigator, Mass Spectrometry

Job description

Nombre del sítio: UK - Hertfordshire - Stevenage
Fecha de publicación: Feb 23 2024

The structural biology and biophysical sciences (SBS) group is a vibrant and global organisation that supports all medicine modalities from traditional small molecule drugs and biotherapeutics to oligonucleotides and vaccines. We are looking for a talented research scientist with expertise in biological mass spectrometry and a particular interest in structural MS and protein characterisation to join us on a permanent, full-time basis.

As the successful candidate, you will work in the mass spectrometry (MS) group within the wider SBS team at GSK’s Stevenage R&D site, where we provide molecular insights that drive design of differentiated medicines and vaccines. Structural MS forms an important part of understanding the molecular mode of action of how our therapeutics engage with protein targets, informing how molecules can be improved and guiding how they are progressed through our pipelines. We have a current focus on HDX-MS and native MS technologies to provide rapid mode of action insights and triage at multiple stages of the drug discovery process.  However, we would particularly encourage applicants with experience in orthogonal peptide centric workflows (covalent labelling or cross-linking strategies). You would regularly participate in and lead project contributions through the integration of MS data with structural models and biophysical data sets.

The group is also responsible for supporting all MS characterisation (intact mass and protein sequencing) for protein reagent generation and design in addition to aiding biopharmaceutical discovery programmes. The group has a record of developing high-end MS methodologies to support the growing complexity of emerging modalities and challenging antigens. Successful applicants would also have the opportunity to help lead the group’s MS QC strategy.

At Stevenage we have a state-of-the-art suite of 6 high resolution mass spectrometers in the group including a Bruker TimsToF, Waters Cyclic IMS HDX Platform and EMR/UHMR Orbitrap instruments.  We also provide an array of biophysical techniques (SPR, Mass photometry, FIDA) and together form a growing structural biology centre of excellence. The group works in unison with project teams across all modalities to generate integrated mode of action data that helps progress projects from concept to medicines.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will

·  Deliver structural mass spectrometry insights and MS QC across multiple projects within our global portfolio of vaccine & pharma projects.
·  Act as a consultant and represent structural & biophysical sciences (SBS) in inter-disciplinary program teams.
·  Maintain connectivity with external science community to stay abreast of science developments.
·  Have responsibility for the MS peptide sequencing platform and develop methodologies to allow analysis of complex samples.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

·  Background in a biological, biochemical, or physical sciences discipline, with PhD level or equivalent industrial experience.
·  Significant experience in biological structural mass spectrometry approaches, ideally peptide-centric workflows.
·  Evidence of independent execution and delivery of high quality data within defined timeframes.
·  Strong communication and teamwork skills; ability to work in a multidisciplinary team and clearly communicate results with team members from different backgrounds.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

·  Instrument experience with Bruker TimsToF platform or high-resolution hybrid/tribrid orbitraps
·  Experience in structural covalent labelling or cross-linking strategies.
·  Experience in instrument maintenance and developing new workflows for LC-MS peptide/protein identification and PTM/modification analyses.
·  MS Experience with working with complex samples (lysates, serum, membrane).
·  Knowledge in MS/MS data processing and interpretation using computational software packages (e.g. Mascot, PMI).
·  Practical expertise with other biophysical methods.
·  Strong track record of publications in peer reviewed journals, or patent filing.
·  Ability to coordinate projects with interconnecting activities.

Closing Date for Applications – 16th March 2024 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert. 
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

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