In vivo immunologist

Job description

Details:

We are a science-led global healthcare company. Our operating model and our business model both are designed to support us in our mission.
We are focused around three core businesses: Pharmaceuticals, Vaccines and GSK Consumer Healthcare.

We have a significant global presence with commercial operations in more than 150 countries, a network of 84 manufacturing sites in 36 countries and large R&D centres in the UK, US, Belgium and China.

We have an exciting opportunity for an In Vivo Immunologist, to join GSK's Respiratory Therapeutic Area as a laboratory-based scientist within the Allergic Inflammation Discovery Performance Unit (AI-DPU) in the United Kingdom (Location: GSK's site in Stevenage).

You will be working in a stimulating and fast moving environment, where we put great emphasis on high quality science. The AI-DPU is a multi-disciplinary team of professionals exploring novel immunotherapeutic strategies for treatment of asthma.

Asthma is one of the most common chronic inflammatory diseases, with an estimated 300 million patients worldwide and an increasing prevalence, in particular among children. It is increasingly realised to be a heterogeneous disease with multiple endotypes, including a major group encompassing allergic asthma which is characterized by IgE antibodies and type-2 cytokine-driven chronic airway inflammation, remodelling and airway hyperresponsiveness.

The AI-DPU develops targets from their initial discovery all the way to proof of efficacy studies of our drug candidates in the clinic, and therefore we have a great focus on the patients we intend to treat.

The successful candidate will devise, coordinate, perform, analyse and interpret in vivo animal experimental studies within a team focusing on the identification and validation of novel asthma targets and associated biomarkers.

Graduate with relevant laboratory experience (immunology including in vivo). UK Home Office personal licence holder or equivalent.

Job purpose:
• Setting up and running in vivo respiratory immunology models in mice and rats
• to model aspects of asthma and asthma exacerbations
• to identify and validate novel targets for future therapeutics
• to explore and characterise impacts of novel therapeutic treatments
• to assist in carrying out inhalation PK/PD studies
Line responsibility: could supervise an IP student after 1-2 years in post
Responsibilities (In vivo Immunologist specific)
• Setting up, characterising and running asthma relevant in vivo respiratory immunology models in mice and rats. Will hold Home Office licence (modules 1-3)
o Inhaled, intra-nasal, intra-peritoneal, intra tracheal, oral and s.c. dosing
o Collection of blood and broncho-alveolar lavage and tissues in rats and mice
o Tissue culture (cell lines and primary cells)
o Flow cytometry for characterising infiltrating and resident cells in tissues and immune and inflammatory cells in lung lavage (including lymphocyte and myeloid sub sets)
o Mediator assays (Luminex, MSD and ELISA)
o Molecular biology (RNA isolation, qPCR)
o Microscopy / histology

Responsibilities (Generic)
• All aspects of data analysis, recording and archiving in eLNB and corporate databases, ensuring overall quality of scientific work.
• Reporting data to multidisciplinary project teams and contributing to project strategy discussions
• Will support work of grade 7 scientists in the group, but depending on experience could become the in vivo lead for aspects of a programme.

When applying for this role, please use the 'cover letter' of the on-line application and/or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

If requiring an adjustment for a disability, once selected for interview you may contact ************@*******.**

Closing date for applications is 4th of October 2016

*LI-GSK

Contact information:

You may apply for this position online by selecting the Apply now button.

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Desired profile

Basic qualifications:

Graduate in immunology, life sciences or related disciplines.

Graduate with relevant laboratory experience (immunology including in vivo).

UK Home Office personal licence holder or equivalent.

Preferred qualifications:

As above