Early Medical Lead, Oncology

Job description

Nombre del sítio: UK - London - Brentford, Baar Onyx, Durham Blackwell Street, USA - Pennsylvania - Upper Providence
Fecha de publicación: Feb 21 2024

Job Purpose

The EML role provides medical leadership to support the rapid progression of assets (Medicines or vaccines) to the Commit to Phase 2 decision gate with indication sequencing, population segmentation and evidence generation plans informed by appropriately prioritised Medical Affairs insights.

This is a unique opportunity for an experienced, innovative and motivated Medical Affairs leader to provide strategic medical leadership for a portfolio of early assets. This is a critical role expected to enable better informed decision making for portfolio progression, earlier incorporation of prioritised medical insights into evidence planning, differentiation and launch readiness, and more rapid progress through early and late clinical development.

Will work alongside Early Development Leaders (EDL) group, and others, in R&D, and with the Portfolio and Pipeline Strategy Group (PPSG) in Commercial, with which it will also provide medical evaluation of Business Development opportunities for the GSK pipeline.

Key Responsibilities

·  To bring critical Medical Affairs leadership to our assets in the early Specialty Care pipeline supporting programs from the Candidate Selection milestone through to Commit to Phase 2 or the appointment of an asset-specific Global Medical Strategy Lead
·  Provide targeted, focused medical leadership to a diverse portfolio of innovative assets focused within aligned disease areas: provide strategic medical insights into R&D and commercialization strategies; profiling patient pathways; mapping the treatment landscape and how it may evolve in the lifecycle of the asset; identifying gaps and opportunities based on emerging data, competitor activity and understanding of diverse healthcare systems; lead on strategies to shape the future practice of medicine within specified and related disease areas
·  Contributing expertise in scientific issues related to clinical development, study design, data interpretation and study conclusions.
·  Deploying strong analytical thinking to quickly assess large amounts of information and distil into key messages and actions.
·  Providing strategic input opinion based on broad knowledge and close study of disease and emerging external environment, with clear focus on patients and unmet medical need. Engage and collaborate with external experts to identify key medical unmet needs, physician perspectives, treatment landscape and payer priorities.
·  Connect closely with LOC Medical Affairs, ensuring key market insights are captured and reflected in strategies in a timely way and are used to validate asset and recommendation assumptions during the technical and commercial review process.

·  Ensure strategic alignment with clinical development and central and regional partner functions, to develop and optimize the medicine profile and evidence generation plans in support of the scientific value proposition of assigned assets and aligns resource needs.
·  Leadership of the global scientific engagement strategy for the asset, including at scientific congresses, advisory boards or other events where appropriate. Drives excellence in scientific engagement with key stakeholders (HCPs, Patients, Payers and Regulators) to gather medical insights and build a deep understanding of customer needs to inform and shape the portfolio’s development programme.
·  Providing Medical input to the review of Business Development opportunities, including but not limited to: determining clinical value through working with external expert partners; input into  determining the patient population and ensuring the lead indication fits the unmet need; determining readiness of the clinical environments for the innovation and what work (incl. EG) must be carried out to shape the practice of medicine; consider the overall IEP and ensure wider understanding of the total “cost” of an asset acquisition is considered.
·  Taking accountability for the asset’s medical governance and for approval of materials and activities to ensure they are compliant with GSK Code of Practice, standard operating procedures, and with external industry standards including the ABPI Code of Practice.
·  Collaborating with partners in Finance and Procurement to manage resources, vendors and budgets and deliver project-critical achievements on time, and to ensure smooth transition to an asset-specific GMAL when appointed.
·  Matrix leadership across multiple teams. Play a key role in delivering on team objectives on medicine development teams.

Qualifications

·  Qualifications - MD/MBBS/PharmD or PhD in clinical / scientific discipline
·  Scientific and Medical Knowledge - Experience of working within oncology or hematology
·  Leadership - Experience in an asset leadership role in Medical Affairs at country and above country level.
·  Medical Affairs - Asset launch experience, with design and execution of in country and above country strategies.
·  Clinical - Experience of the required steps to progress a new chemical lead through the stages necessary to allow it to be tested in human clinical trials.
·  Clinical Development - Experience in the design, development, execution, statistical analysis, clinical interpretation and reporting of high-quality clinical studies.
·  Agility - Experience of assimilating information rapidly to identify critical questions that will drive decision-making and planning.
·  Strategic Thinking - Experience of carefully considering the issues and competing priorities within a situation, program or portfolio and then developing a strategy that includes the strategic application of available principles, tools, and systems.
·  Business Acumen - Experience of making decisions related to human, financial, material and information resources and using this knowledge to plan medical affairs strategy and resourcing.
·  Reimbursement/Market Access Knowledge - Experience of working closely with Value Evidence and Outcomes groups to support the payer value proposition.
·  People Development and Performance Management – Experience of building and maintaining a high performing team with appropriate performance management

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