Computational Antibody Engineer

Job description

Your Responsibilities :
GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Biopharm Discovery is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery,
expression and characterisation to molecular engineering and biological and physiochemical profiling. Computational Sciences is a department dedicated to directly applying and broadly enabling R&D to embed the principle of ‘predict-first' to drive design and development of safe and efficacious medicines for patients.

This department comprises several complemetary groups focused on computational chemistry, predictive toxicology, systems biology and biopharmaceuticals.

Within the Computational Sciences Deptartment, the Protein Design and Informatics (PDI) group takes accountability for computational support of Biopharm Discovery. An opportunity has arisen for a computational antibody engineer with experience in computational molecular design to aid in driving all aspects of molecule quality such as affinity maturation, developability, safety and efficacy.

He/she will have the opportunity to work closely with the experimentalists, while developing and apply cutting edge computational techniques to advance biopharmecutical development .

You are an enthusiastic, dynamic and self-motivated computational scientist with technical expertise in the field of protein structure bioinformatics. In this role he/she will apply computational design tools for designing and engineering of antibodies such as rational library design, de novo antibody design, optimization of protein stability, humanization, and decreased immunogenicity.

The role also involves important aspects of verbal and written communication and requires good organisation as well as a broader scientific knowledge. Both individual and team working are required and therefore the role will suit a scientist with good interpersonal skills, abilities in data analytics, self-motivation and an open mindset.

We can offer you a collaborative learning environment and the opportunity to develop your career and gain experience across drug discovery. If you share our priorities of innovation, performance and trust and are motivated to contribute towards bringing lifesaving drugs to patients, then we'd love to hear from you.

closing date: 29th May 2019

Please use your cover letter to highlight how you meet the competencies for the role, your cover letter along with your CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

GSKBiopharm_Discovery
*LI-GSK

Why You?

Basic qualifications:
• PhD or equivalent in Computational Chemistry or Biology, Bioinformatics, Physics, or Chemistry
• Experience in protein structural analysis with an emphasis on protein visualization software, protein homology modeling and simulation, rotomer and loop exploration, and protein/protein docking.
• Familiar with protein design tools e.g. as implemented in Rosetta, Schrödinger, MOE or equivalent.
• Proficient in one or more programming languages (e.g. Perl, C/C++, Java or Python, Ruby)
• Competent working in a Linux/Unix environment
• Demonstrated ability to work in multi-disciplinary matrix teams, displaying excellent interpersonal skills
• Strong organisational and communication skills (both written and oral), with the ability to liaise with scientists and external collaborators at all levels
• Ability to independently review and appraise scientific literature
• Ability to generate conclusion reports, present data in team meetings and participate in writing of abstracts and publications

Preferred qualifications:
• Experience with high performance computing and/or cloud computing.
• Experience with machine learning algorithms
• Experience with sequence and structure of antibody repertoires and bioinformatics tools utilized in their analysis
• Training in statistics

Why GSK? :
GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Contact information:
You may apply for this position online by selecting the Apply now button.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

jobDetails