PhD Student in the Radio-Oncology Lab

Job description

PhD Student in the Radio-Oncology LabContexteThe Lausanne University Hospital (CHUV) is one of five Swiss university hospitals. Through its collaboration with the Faculty of Biology and Medicine of the University of Lausanne and the EPFL, CHUV plays a leading role in the areas of medical care, medical research and training.
The team of Research in Radio-Oncology at the CHUV/Lausanne has been the first to develop a novel modality of radiotherapy called FLASH radiotherapy (FLASH-RT) that has the potential to revolutionize radiotherapy treatment in the near future, making it safer and more efficient. Using various biological studies, we have shown that FLASH-RT was able to eliminate cancer cells without causing any collateral damages to the normal tissue whereas classical radiation therapy, used for the treatment of cancer patients, eliminates cancer cells but causes damages to the surrounding normal tissue and unwanted side effects. FLASH-RT treatment is delivered very quickly in microsecond whereas several minutes are required for a treatment with classical radiotherapy. This very short time of exposure protects the normal tissue and change the way biological tissues respond to FLASH-RT. While, we are in the process of translating FLASH-RT in clinical trials, we obtained funding to investigate and characterize the response of tissues to FLASH-RT at the physical, chemical and biological level. This multidisciplinary project will involve several PhD and post-doctoral fellows working together with permanent researchers.MissionThe PhD student will evolve in the unique and stimulating scientific environment of the Swiss Cancer of Lausanne and will work in a multidisciplinary team, on one of the most innovative subject in Radio-Oncology. In addition to be working on the a novel FALSH-RT approach, The selected PhD student will work with an innovative biological model based on the use of zebrafish embryos. The candidate will be specifically be in charge of investigating the biological cascade and the reactive oxygen species contribution activated after FLASH irradiation along three main axis:

H2O2 measurement in cell line and Hyper zebrafish.
Regulation of antioxidant pathway by FLASH-RT.
Impact of oxygen metabolisms on immune response in tumor and normal tissue.
ProfilA strong biology background is needed (Master 2), knowledge in radiobiology and/or in free radical chemistry would be a plus but above all the candidate must be curious, open-minded and team player.Nous offronsIf you become an employee at the Centre Hospitalier Universitaire Vaudois, we will offer you the following :

High social benefits
Regular salary progression according to job responsibilities
Three days of training per year
25 working days of vacation per year
Very good restaurants with preferential rates.
Contact et envoi de candidatureContact for information on the function : Dre Marie-Catherine Vozenin, marie-Catherine.vozenin@chuv.ch
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The CHUV applies the highest quality requirements as part of its recruitment process. In addition, mindful to promote the diversity of our employees we are attentive to the different life courses and strive to ensure equal treatment and avoid any discrimination. We are looking forward to receiving your application.
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