Offers “Sanofi”

Expires soon Sanofi

Formulation Research Scientist

  • Cambridge (Cambridgeshire)
  • IT development

Job description



Essential Duties and Responsibilities:

·  The candidate will work in area of design, optimization and improvement of vaccine formulation, esp. lipid nanoparticles formulations, for the delivery of vaccines, including nucleic acids-based vaccines.
·  The work is multi-functional and includes formulation design and optimization, analytical methods development, physical characterization, scale-up chemistry and interpretation of results.
·  The candidate with be expected to have a leadership role in the efforts on the synthesis of novel excipients and interact closely with other researchers in research and development of novel delivery formulation.
·  This is a hands-on, laboratory-based role in a highly collaborative early development environment. Role will require planning, designing, executing, interpreting, and present data in an effective and scientific manner.
·  Participate in scientific discussions related to out-sourced activities or technology transfers with CROs
·  Lead a team of scientists to identify and optimize vaccine formulations aimed at accelerate existing while keeping update with emerging technologies.
·  Provide scientific and technical inputs to support formulation activities with an overall objective to facilitate R&D portfolio progression, introduction of state of art technologies and maintenance of a competitive Research environment
·  Ensure exchange of ideas and technologies across platforms and departments at Sanofi, leveraging appropriate expertise and input.
·  Responsibility to interface and collaborate with Head of Research North America and Head of RNA technology to ensure global strategic alignment in support of Projects, within Research and other functions of Sanofi Pasteur.

Job Requirements:

·  Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, Biomedical Engineering or closely-related discipline with an emphasis in formulation science and lipid nanoparticle research. M.S. in similar fields acceptable with a minimum of 10+ years of relevant industrial experience.
·  Experience with lipid nanoparticle delivery of RNA or DNA and knowledge of design, synthesis, characterization and structure-property relationships of lipids and other lipid-like molecules is required.
·  Experience in formulation optimization for improvement of potency and stability of vaccine formulations, preclinical formulation development and analytics is expected.
·  Experience and technical proficiency with HPLC, gel-based and other methods for analysis and quantification of small molecules, DNA and proteins is preferred.
·  Familiarity and technical proficiency in the physical characterization of nanoparticles, including particle sizing and lab-scale nanoparticle preparation techniques, including microfluidics technology, is preferred.
·  Experience with alternate pharmaceutical manufacturing technologies homogenization, lyophilization, aerosol formulations, filling and packaging etc. is a plus.
·  Strong interpersonal, communication, collaboration and problem-solving skills are needed.
·  Track record of scientific publication and conference presentation are needed.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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