Structural & Biochemical Informatics Investigator/CADD

Job description

Job Description

The Computer-Aided Drug Discovery (CADD) team in Cambridge brings together diverse skill sets in helping NIBR discovery teams validate and drug new targets. We are seeking a unique computational scientist to complement the team with the skills, experience and passion to extract new knowledge and disruptive insights from the large and rich body of data collected by the one of the world’s oldest pharmaceutical companies. Working with a wide variety of multi-disciplinary scientists, you will help devise creative solutions to drug discovery problems and innovative paths to new medicines.

Summary of duties:
• Develop and apply innovative computational approaches to predict biological activity profiles of small molecules and peptides utilizing proteochemometrics, biochemical modeling, structural bioinformatics, quantitative chemogenomics, computational metabolomics, computational systems biology, computational epigenomics, statistical genetics, translational genomics, etc.
• Keep abreast of scientific literature and interact with internal and external scientists to integrate biological insights into lead characterization and screening efforts.
• Collaborate with interdisciplinary project teams to drive effective decision-making from target identification through candidate nomination by mining and developing predictive models using high-content and time-resolved screening data, including imaging.
• Drive hypothesis generation to result in higher clinical success rates for programs utilizing small molecules peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors and kinetic stabilization of drug-target complexes.
• Perform experimental work related to project objectives and reports laboratory activities, fully responsible for adherence to Novartis global standards e.g. quality, safety, data security, productivity, innovativeness, timelines and cost effectiveness.
Posting Title

Structural & Biochemical Informatics Investigator/CADD

Desired profile

Minimum requirements

Education:
• Advanced degree in computational chemistry, computational biology, computational chemical biology, or related field. PhD strongly preferred. Candidates with an experimentalist background and strong computational experience are also encouraged to apply.

Experience:
• 3-5 years of experience with general machine learning (use to build AI systems).
• Programming experience (R, Python, Matlab, Java).
• Experience using machine learing libraries, such as scikit-learn TensorFlow and Theano
• Strong publication history in peer-reviewed journals.

Skills and Abilities:
• Strong statistical foundation with broad knowledge of deterministic and probabilistic statistical methods.
• Good listener. Strong, concise, and consistent written and oral communication.
• Knack for communicating stories through data visualizations.
• Familiar with the foundational concepts in molecular biology, pharmacology or medicine.
• Experience with NGS, proteomics, and other high-throughput assays a plus.
• Provide leadership for ad-hoc data analysis, visualization and statistical support throughout the organization
• Working knowledge of medicinal chemistry and drug discovery.
• Proven ability to collaborate with others.
Job Type

Full Time
Country

USA
Work Location

Cambridge, MA
Functional Area

Research & Development
Division

NIBR
Business Unit

Global Discovery Chemistry
Employment Type

Regular
Company/Legal Entity

NIBRI
EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.