Offers “Roche”

37 days agoRoche

Scientist/Sr Scientist, iPSC and Genetic Engineering Technologies

  • San Francisco (City and County of San Francisco)
  • Teaching

Job description

·  Job facts

The Molecular Biology Department is seeking a Scientist/Sr. Scientist to establish a research group focused on induced-pluripotent stem cell (iPSC)-based in vitro model and technology development. This new team will help to enable Genentech's Translational Genomics efforts, which span the interface of human genetics, functional genomics, molecular biology, cellular and tissue profiling, disease model engineering, and advanced computational methodology.

The successful candidate will hire research staff and build a complex cell model platform with the goal of improving our understanding of human biology and therapeutic interventions. Candidates with an eagerness to work within a team-driven, dynamic research environment will be prioritized. The candidate will work in close collaboration with Genentech's Advanced Cell Engineering (ACE) hub, which comprises a growing team of expert cell, molecular, developmental biologists, and genome engineers focused on creating disease model systems for exploratory or pre-clinical research projects. Expertise developing and/or applying in vitro systems (i.e. cell lines, organoids, iPSCs) is critical. Practical experience with in vitro model development for neurodegeneration, regenerative medicine, infectious disease, and/or oncology is desirable.

In addition to direct collaborations with our therapeutic area leaders, the successful candidate will establish an independent research program with the goal of informing early and late stage pipeline efforts. The Scientist/Sr. Scientist will interface with Genentech's next-generation sequencing (NGS), functional genomics, cell or tissue profiling, and bioinformatics teams to enhance our analytic capabilities, and incorporate cutting-edge large-scale genetic screening or single-cell technologies to reveal the underlying mechanisms of human disease.

Requirements:

· 
PhD in Genetics, Molecular Biology, Developmental Biology, Biochemistry, Oncology, Infectious Disease, Regenerative Medicine, Neuroscience, or related field

· 
4+ years of post-doctoral experience in similar fields

· 
3+ years of experience establishing disease models from human iPSCs; hands-on experience with both 2D and 3D co-cultures a plus

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Practical expertise with advanced genome editing tools (CRISPR, RNAi, degrons, etc.) and applications for cell engineering or functional genomic screens

· 
Experience with cellular reprogramming highly desirable

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Experience developing or analyzing single cell assays (RNA, ATAC, spatial transcriptomics, etc.) is advantageous

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Sustained, impactful record of scientific contributions and documented evidence of iPSC-related expertise, as evidenced by publications, patents, and presentations

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Demonstrated leadership capability both within and across teams

· 
Exceptional organizational and communication skills

Responsibilities:

· 
Build/Lead a foundational stem cell model engineering and chemo/genomic screening unit to drive Translational Genomics efforts

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Routine engagement with Genentech group leaders and Model Project Teams to co-develop research and technology-focused programs

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Regular and effective communication with internal and external partners

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Identify, evaluate, and engage new CRO or partnering opportunities to enhance throughput

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Collaborate effectively with informatics and software development teams

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Incorporate state-of-the-art screening, imaging, and/or automation solutions for stem cell culture and method development

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Establish an industry-leading, externally-recognized research program, publish discoveries in high-impact journals, attend and present at conferences

#translationalgenomics

·  Who we are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

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