Offers “Roche”

36 days agoRoche

PostDoc Ocular modeling and experimental approaches to support the development of half-life extension technologies (m/f/d)

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Job description

·  Job facts

The position

This position is sponsored by the Roche Postdoctoral Fellowship (RPF) program, which aspires to provide talented researchers with the chance to collaborate with leading Roche scientists and academic research groups from around the world. A key goal is to advance basic science and technologies to be shared in scientific publications and patent applications, as needed.

As an RPF Fellow in Roche Pharmaceutical Research and Early Development, you will focus on exploratory research of long-acting delivery technologies for large molecule drug candidates with application to eye diseases. This project is jointly mentored by the Large Molecule Research and Pharmaceutical Sciences departments. We are now looking for an extraordinary, highly motivated, and talented Postdoc to join our team in an outstanding scientific environment.

In this position you will be responsible for the following topics:

Establishing in vitro methods for the assessment of complex matrices and tissues of the eye

Studying the capacity of eye tissues for delivery of therapeutic proteins and the changes associated with age and disease

Investigating the diffusion behavior of large molecule (antibody) drug candidates in eye tissues of different species, including human, and the relation to biophysical and functional properties

Generating rich and high quality in vitro datasets that you will analyze with statistical and mechanistic modeling approaches

Extracting quantitative insights to inform the translation from in vitro to in vivo and from animal to human

The requirements for this position:

We are seeking a highly motivated scientist who possesses solid experience in the laboratory. Therefore, you bring the following for this position:

Significant experience in biophysical analytical methods with solid experimental and scientific expertise in fluorescence correlation spectroscopy or related technologies

Experience with statistical analysis and pharmacokinetic/dynamic modeling. Education in applied mathematics, physics, modeling and simulation is of advantage

Fluency in spoken and written English

A substantial track record of scientific publications and presentations

A dedicated, hands-on attitude and curiosity to establish innovative experimental and modeling techniques

Furthermore, you have been actively engaged in scientific research continuously since your PhD (MD or MD/PhD)

You have very good interpersonal and communication skills

You are able to build good working relationships and are an outstanding teammate

Your experience and investigative attitude allows you to work independently and to design, perform, and interpret experiments

The duration of the fellowship

The duration of the RPF fellowship is initially set for two years, with the possibility of extension for a third year. You will be based at the Roche Innovation Center Munich with regular visits to our headquarters in Basel. You will also be connected with our academic partners who will share the mentorship of this project.

When does the fellowship start?

The earliest start date of this fellowship is April 2021 or on availability. Please clearly indicate your preferred starting date on your motivation letter.

More information about the RPF Programme:

This position is fixed-termed to two years.

We look forward to receiving your application!

Your application documents:

All applications need to include a CV, motivation letter, publication list and, if available, your PhD diploma.

Do you have any questions about the current application status or about the job in general ?

Our FAQ provide answers to many questions. And if you haven't found the right answer, our Talent Acquisition Team is ready to help you!

You can reach us Monday to Friday from 9-12 am and from 1-4 pm by phone: 0621-759 68642.

·  Who we are

With more than 12,000 employees Roche Diagnostics GmbH (RDG) represents the third largest site within Roche. Apart from the two sales organizations in Germany (Roche Pharma AG and Roche Diagnostics Deutschland) RDG is focused on the operative business. At the two sites in Mannheim and Penzberg new diagnostic tests and pharmaceutical active ingredients are developed and produced for the global market.

Roche is an equal opportunity employer.

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