Offers “Roche”

Expires soon Roche

Disease Modeling Scientist_2 year temporary contract

  • CDD
  • Basel (Bezirk Arlesheim)
  • Chemistry / Biology / Agronomy

Job description

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. 

These positions are located in the Predictive Modeling and Data Analytics (PMDA) chapter, a chapter within the Pharmaceutical Sciences function, where Disease Modeling is a primary focus area. 

As disease modeler, you contribute to the decision making process by designing and executing the disease modeling strategy for programs at different stages of research discovery or early clinical development in one or several disease areas. You closely collaborate with colleagues in PMDA chapter, in the Disease Therapeutic Areas (DTAs) and in the functions such as clinical pharmacology, biostatistics and pRED informatics to convert hypotheses into innovative therapeutics.
Your work will focus on understanding disease state temporal dynamics and the impact of pharmacological treatments on its time course by developing quantitative system pharmacology (QSP), pharmacokinetic/pharmacodynamic (PK/PD), statistical or machine learning models. 

Your Responsibilities include:

  • Define, develop and execute scientifically sound, innovative and business-oriented Disease Modeling & Simulation (DM&S) strategic plans for projects in various disease areas and at different stages of research discovery or early clinical development.

  • Develop system pharmacology, PK/PD, statistical or machine learning models that integrate preclinical/clinical data and knowledge on pathophysiological mechanisms, patient characteristics and drug pharmacology.

  • Conduct clinical trial simulations to inform drug development decisions such as dose, regimen and other trial design features, mechanism of action, and patient selection.

  • Communicate the outcome of DM&S analysis to the project teams to support efficient discussion and decision making.

  • Interact on a scientific level with partners in project team(s) with regards to all aspects of the application of DM&S to ensure efficient and appropriate integration of DM&S strategy and results into internal and external project documents (e.g. Clinical Development Plan, Health Authorities briefing books)

Your profile

Essential qualifications:

  • PhD applied to life sciences in the fields of mathematical modeling, computational biology, biophysics, applied mathematics, machine learning or biostatistics;

  • Strong analytical skills, with ability to understand and develop mathematical/statistical methods and to translate them into a computational algorithm;

  • Solid expertise in analyzing longitudinal preclinical/clinical data by developing PK/PD, QSP and disease models from first-principle using domain expertise knowledge; 

  • Strong computational and coding skills and proficiency in at least one high level scientific language (such as R/MATLAB/Julia/Python)

  • Excellent communication and writing skills in English as well as a proven track record of publishing in peer reviewed journals.

Desirable qualifications:

  • Experience with population approach  (e.g. non-linear mixed effect models, Bayesian hierarchical models) and M&S software (e.g. NONMEM, Monolix, nlmixr, Pumas-AI, Stan);

  • Experience in exploratory data analysis and machine learning methods (e.g. regression, classification, dimensionality reduction, ensemble methods, neural nets and deep learning) ;

  • Background in pharmacology, life sciences or medicine with a clear interest in clinical research and in developing deep understanding of disease biology;

Ways-of-working:

  • Flexibility and capability to work independently

  • Strategic mindset and understanding of how and when M&S can contribute value in drug development and support decision making.

  • Ability to influence and lead without authority in a network organization

  • Able to radically simplify and prioritize for impact. You invest your time in things that accelerate progress for patients. You stop doing things that do not.

Your location

This position is located in Basel.

 You’re someone who wants to influence your own development. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. 

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

Job Level:

Individual contributor

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