38 days agoLimagrain

Post-doctoral position (H/F)

  • CDD
  • FRANCE
  • Chemistry / Biology / Agronomy

Job description

Description du poste

Famille de métier

RECHERCHE ET INNOVATION - INNOVATION

Type de contrat

CDD

Durée du contrat

24 mois

Temps de travail

Temps complet

Finalité du poste

The research teams Human Research Unit (UNH, UMR 1019, contact person: Florence Caldefie-Chezet) and Microbiology, Digestive Environment and Health (MEDIS, UMR 454, contact person: Stéphanie Blanquet-Diot) from Université Clermont Auvergne in France, together with Limagrain Ingredients Company (contact person: Pierre Berbezy), is recruiting a post-doctoral student for a two-year position in the frame of the Plan France Relance. The objective of the common project is to assess the potential of high-amylose resistant starch to stimulate human immune cells and evaluate how this effect can be modulated by gut microbiota, by using complementary in vitro tools. The project will be divided in three main WPs: 1- Improvement of technical processes and food matrices to obtain high resistant starch containing foods with low glycaemic response and low glycaemic index, 2- Fermentation and impact of high resistant starch products on human gut microbiota by using a validated in vitro model of the human colon, 3- Effect of fermented samples on oxidative and inflammatory pathways in human immune cells. The post-doctoral student will be involved in all the steps of the project in close relationship with the academic and industrial partners.

Missions

-        Perform a literature review on resistant starch, gut microbiota and immune system in humans

-        Carry out experimental assays to optimise resistant starch content in food matrix and characterise the resulting products (biochemical and sensorial analyses, in vitro digestion and determination of glycaemic response and glycaemic index)

-        Perform in vitro fermentations in the human colonic ARCOL model and associated metabolic analyses (gas and short chain fatty acid measurement)

-        Prepare fermentation samples for metabarcoding analyses of gut microbiota and further cellular assays

-        Perform in vitro cellular tests on immune cells

-        Realise descriptive and statistical analyses of results generated, including bioinformatics analyses of sequencing data

-        Participate in data management/storage and laboratory/company life

-        Contribute to data valorisation in internal and external meeting and conferences

-        Write review articles and publications

Profil

REQUIRED SKILLS

Knowledge

-          Biology: food science, digestive physiology (especially gut microbiota), microbiology, biochemistry, cellular and molecular biology

-          Competences in bioinformatics and biostatistics would be greatly appreciated

-          Skills in English language, knowledge of the host-country language (French) would be an added value

Operational skills

-          Advanced skills in aerobic and anaerobic microbiology, continuous fermentation systems and cell culture

-          Skills in in vitro digestion and food formulation would be an added value

Behavioral skills

-          Ability to organise work and team-building spirit

-          Thoroughness and motivation

-          Communication skills

-          Ability to carry out a multidisciplinary project

PREREQUISITES / DESIRED TRAINING:

PhD diploma in biology after September 2019, microbiology and molecular or cellular biology.

Advanced skills in microbiology, cell culture and complex in vitro digestion/fermentation systems would be a benefit.

 

SPECIFICITIES OF THE POSITION:

A driving licence will be necessary to join the different sites of the project (Université Clermont Auvergne, Clermont-Ferrand and Limagrain Ingredients, Riom, < 30 km). The associated costs will not be re-funded (included in the salary).

Gross salary of 2800 €/month for a total amount of 1607 hours/year.

 

TO APPLY :

The application form should contain a motivation letter, a detailed CV including a listing of publications, a copy of the PhD diploma and letters of recommendation by previous supervisors. 

Please send before the 1st of December 2021 to planderelance.drv@uca.fr.

Localisation du poste

Localisation du poste

Europe, France, Auvergne, Puy de Dôme (63)

Lieu

32 Avenue Georges Gershwin, 63200 Riom, France

Critères candidat

Niveau d'études min. requis

Doctorat ou équivalent

Spécialisation

R&D

Niveau d'expérience min. souhaité

jeune diplômé

Autres

***Attention : les candidatures doivent être adressées à planderelance.drv@uca.fr

Langues

·  Français (3 - Opérationnel)
·  Anglais (3 - Opérationnel)

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