Protein Purification Scientist

Job description

Details:
GlaxoSmithKline (GSK) is one of the world's leading research-based pharmaceutical companies. Our powerful combination of skills and resources provide the platform for delivering strong growth and the platform for responding quickly to the rapidly changing global healthcare environment. We are a science-led global healthcare company that researches and develops a broad range of innovative products in three primary areas of Pharmaceuticals, Vaccines and Consumer Healthcare. We have a significant global presence with commercial operations in more than 150 markets, a network of 86 manufacturing sites in 36 countries and large R&D centres in the UK, USA, Spain, Belgium and China.

BPR (BioPharm Process Research) straddles biology discovery and product development. We are in the exciting world of developing new purification processes and then transferring them to manufacturing for phase 1 supply. We work with a range of molecules from the more challenging molecules such a domain antibodies and recombinant proteins to molecules such as mAbs that render themselves amenable to platform purification, characterising any risks and beginning to identify critical quality attributes. The downstream group is diverse in every sense hence an easy fit for new starters.

We are currently recruiting a Protein Purification Scientist to be based in Stevenage, Hertfordshire, UK. This role will see you working with the team in order to support process development activities.

The successful candidate will be involved with a diverse range of activities including:

• Assisting in the timely development of outline downstream processes which can be scaled up to clinical supply and risk highlighting packages
• Use of high-throughput automation in process development.
• Staying current with Downstream Development technology improvements and implement according to business need
• Working with key customers (eg Process and Analytical Development) to ensure alignment of processes and practices.
• Assisting in the successful and timely transfer of processes to and from testing labs or scale up development group.
• Contributing to project and matrix teams as appropriate
• Seeking all opportunities to develop and maintain a strong IP position.
• Maintaining relationships with external professional, trade, and scientific organisations consistent with GSK business needs.

If requiring an adjustment for a disability, once selected for interview you may contact

Closing date for applications: Wednesday 17th May 2017.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Thank you for your interest in this opportunity.

*LI-GSK

Contact information:
You may apply for this position online by selecting the Apply now button.

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Desired profile

Basic qualifications:
• BSc, MSc or PhD in Biochemistry, Biochemical Engineering or equivalent.
• Background in Protein Sciences and Biomanufacturing.
• Must be competent in running AKTA platforms such as AKTA Avant, AKTA Explorer and AKTA Pilot.
• Must be able to perform quantitative and qualitative protein assay techniques.
• Experience of working on complex research projects both as an individual and as part of a team.

Preferred qualifications:
• Excellent planning skills.
• Good communication skills.
• Understanding of common downstream processing unit operations and Bioprocess development (with a focus at the early stage).
• Familiar with Critical Quality Attributes (CQAs) and Quality by Design (QBD) concepts and approaches.
• Understanding of how the production of a protein can impact its structure and function and vice versa.