Principal Bioanalytical Scientist

Job description

Your Responsibilities :
GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Biopharm Discovery is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling.

Within the Biopharm Discovery Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling prior to candidate selection to continuously improve molecule quality and transform discovered leads into potential therapeutics.

We are currently seeking an experienced laboratory scientist with a deep understanding of antibody analytics to join the developability profiling group within MDE. The predominantly lab-based role will involve developing and performing high throughput analytical methods/screens (existing and/or new) to rapidly profile a large panel of biopharmaceuticals based on their biophysical and chemical stability properties. The candidate will be expected to act as a Subject Matter Expert (SME) in antibody analytics and characterisation in order to recommend selection of suitable candidates that produce the desired developability characteristics.

You will have the opportunity to both lead projects and build capability, for example in automated workflows, and will be expected to influence scientific direction within the group.

The successful candidate will have extensive experience in characterizing antibodies in analytical techniques such as mass spectrophotometry, light scattering, HPLC, spectroscopy etc. They will be abreast of the latest literature and developments in the field. Although predominantly lab-based, the role also involves important aspects of verbal and written communication and requires good organisation as well as a broader scientific knowledge. You will be expected to develop, train and mentor junior members of staff, and will have demonstrated problem solving skills. Both individual and team working are required and therefore the role will suit a scientist with good interpersonal skills, abilities in data analytics, independence and self-motivation.

Closing date for applications: 2nd December 2019

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Thank you for your interest in this opportunity.

GSKBiopharm_Discovery
*LI-GSK

Why You?

Basic qualifications:
• PhD or equivalent in analytics, biochemistry, biophysics or related discipline
• Demonstrable extensive post-graduate experience in antibody analytics either in academic or industrial setting (e.g. in early discovery/CMC analytical)
• Extensive experience of profiling biopharmaceuticals in a range of analytical methods, such as: mass spectrophotometry, light scattering, SEC-HPLC, RP-HPLC, fluorescence/UV spectroscopy etc.
• Ability to recognise CMC-relevant liabilities of biopharmaceutical molecules
• Experience of leading projects or initiatives with the ability to plan, co-ordinate and deliver complex work packages
• Experience of applying biophysical and biochemical analytical methods to a range of antibody molecular formats
• Deep scientific knowledge of antibody sequence/structure-function relationship
• Extensive experience of analytical and data interpretation skills; strong written and verbal communication skills
• Strong attention to detail in experimental setup; capability to multitask and run multiple experiments in parallel, good organisational and prioritisation skills
• Quick adaptability in new scientific areas, collaborate across teams; ability to review and assimilate new information effectively

Preferred qualifications:
• Experience in liquid handling automation systems
• Experience of developing high throughput methods/assays
• Experience of automated data analysis and/or visualization software
• Experience of developing miniaturized assays
• Knowledge and/or practical lab experience in some or all the areas listed below:
o Protein purification
o Chemical Manufacturing control (CMC)

Why GSK? :
GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Contact information:
You may apply for this position online by selecting the Apply now button.

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