Offers “Gsk”

Expires soon Gsk

Investigator Discovery DMPK in vitro Team

  • Stevenage (Hertfordshire)
  • Energy / Materials / Mechanics

Job description



Your Responsibilities :
Reporting to the in vitro team leader within Discovery DMPK Stevenage Site you will be primarily responsible for implementing and conducting routine in vitro mechanistic studies, generating ADME data to aid in the lead optimization, precandidate profiling and the clinical translation of NCEs and to provide information to develop predict first models to aid medicinal chemistry design.

Working with DMPK project team representatives you will help to solve bespoke in vitro ADME project issues and therefore a background in transporters or enzymology is required. Utilising state of the art automation you will be responsible for validating and implementing in vitro assays and exploring novel technologies for generating in vitro data. This role will be heavily reliant on automation and a strong background in end to end automation including liquid handling robotics (e.g. Hamilton STAR) is desired.

The position will be responsible for the delivery of in vitro DMPK data that will influence and direct new chemistry during the design-test cycle and discovery and development project direction.

Key Responsibilities include, but are not limited to:
• Designing and implementing in vitro ADME experiments
• Implementing and validating in vitro ADME assays on liquid handling robotics
• Performing routine in vitro DMPK screening assays to generate high quality and timely data
• Contributing to the evaluation and development of novel technologies to generate ADMET preclinical data
• Training staff within the DMPK department in, in vitro ADME sciences and automation
• Working with DMPK project team representatives to solve bespoke in vitro ADME project issues
• Representing the in vitro team at cross functional meetings
• Engaging with business partners and providing recommendations based on generated data
• Responsibility for developing and applying adequate knowledge of in vitro ADME sciences to keep up to date with latest industry trends.
• Innovation and problem-solving to overcome in vitro assay design issues.
• Decision making and influencing skills in a DMPK environment, contextualising data with respect to developability and predicted human parameters, including dose.
• Ensuring data generated, from within and external to GSK, meets appropriate standards and that archiving & data integrity compliance is achieved.

Closing Date for Applications: Monday 12th August COB

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the ‘cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
*LI-GSK
GSKGenetics

Why You?

Basic qualifications:
• BSc or equivalent degree in Life sciences or related science such as Drug Metabolism, Pharmacology, Biology, Toxicology, Biochemistry, Physiology
• Extensive experience, up to date knowledge and excellence in the area of in vitro ADME sciences
• Extensive experience of automation and liquid handling robotics in a drug discovery environment
• Strong understanding of key DMPK disciplines
• Proven ability to integrate and interpret in vitro ADME data
• Extensive experience working in a fast-paced pharmaceutical or CRO environment
• Experience of report writing for key decision documents
• Excellent communication, interpersonal and team working skills

Preferred qualifications:
• MSc or PhD in relevant discipline
• Experience in programming Hamilton software (Venus)
• Experience of handling cell-based systems (aseptic) techniques will be an advantage
• Experience of operating and knowledge of LC-MS/MS
• Application of data visualization tools such as Tibco Spotfire to capture and analyse metrics would be an advantage.

Why GSK? :
GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative medicines and brands. We discover, make and market life-enhancing products that are used by millions of people around the world, helping them to do more, feel better and live longer. We have 3 primary areas of business in pharmaceuticals, vaccines and consumer healthcare. We have offices in more than 115 countries, major research centers in the UK, USA, Spain, Belgium and China and an extensive manufacturing network with 87 sites globally. Our three strategic priorities are to grow a diversified global business, deliver products of value, and to simplify our operating model.

Contact information:
You may apply for this position online by selecting the Apply now button.

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