In vitro Biologist

Job description

Details:
The Protein Degradation Discovery Performance Unit (DPU) is developing a new therapeutic modality which aims to harness cellular protein regulation mechanisms via the ubiquitin-proteasome system to reduce levels of disease-causing proteins within cells. This approach gives efficacy typically associated with siRNA approaches but with all the advantages of dosing convenience and bio-distribution of a small molecule. The technology represents a novel and exciting approach to drug discovery which is being applied across a number of areas including inflammation, respiratory disease & oncology with the potential to extend to a wide range of additional diseases and pathologies. The DPU has a portfolio of pre-clinical projects currently advancing rapidly towards clinical evaluation as well as a number of exploratory efforts to expand the reach of the approach.
To help accelerate efforts to apply this exciting new technology, an opportunity has arisen for a highly motivated and skilled lab-based biologist to join our team supporting current and future programmes, projects and biomarker development and play a significant role in advancing our portfolio of programmes. The biologist must be highly innovative, proactive and effective in a collaborative and matrix-working environment.

Accountabilities/responsibilities will include the following:

• Design, validate, conduct and analyse biological/pharmacological assays to provide biological data to programme teams.
• Development of methods appropriate for detecting target engagement and pathway modulation in cell lines, primary cells and tissue assays.
• Interpretation and communication of key data related to projects and capability developments.
• Quantitative analysis of pharmacological data to provide information such as potency, efficacy and kinetic measurements to programme teams.
• May support experimental strategies for in vitro aspects of in vivo pharmacological investigations.
• Authorship of internal experimental reports on candidate compound pharmacology supporting candidate selection/clinical investigator brochures.
• Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practice and support of operational working practices of the DPU as required.

Application Closing Date: 31st January 2017

Please indicate within your cover letter if you are confirmed as displaced (or potentially displaced) and at risk of redundancy.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above.

Thank you for your interest in this opportunity. The information that you have provided in your cover letter and CV will be used to assess your application.

Contact information:
You may apply for this position online by selecting the Apply now button.

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Desired profile

Basic qualifications:
• Graduate degree in a biosciences discipline
• Demonstrated expertise and/or experience in high quality drug discovery or medical research into disease mechanisms.
• Design, execution and quantitative analysis of primary cellular or tissue based assays
• Demonstrated strong interpersonal and communication skills to facilitate matrix and line team working
• Demonstrated ability to coordinate and prioritize work
• Effective problem solving skills
• Effective data analysis and interpretation.
Behaviours required for this role:
• Explores possibilities, creates options, evaluates different courses of action
• Ensures individual work contribution supports the team's goals and the organisational priorities and applies sound judgement to all activities
• Builds trusting relationships within and beyond team to achieve goals and contributes to the success of the broader team/organisation
• Engages constructively with others and demonstrates a positive mindset
• Equips oneself with the skills and knowledge to do excellent work and supporting others to do the same
• Holds oneself and others accountable for delivering quality results

Preferred qualifications:
• Graduate/PhD experience relating to biosciences/medical research
• Previous industrial experience