Offers “Cea Fr”

20 days agoCea Fr

ANR BIOLLPS Engineer H/F

  • CDD
  • 7-12 months
  • Bagnols-sur-Cèze (Gard)

Job description

We are seeking a highly motivated engineer to join our dynamic research team and contribute to the exciting field of liquid/liquid phase separations (LLPS) that are at the basis of rabies viral replication. You will have the opportunity to utilize and develop cutting-edge light scattering techniques with best current dynamic range linked to effective cross section determination, to investigate the underlying mechanisms and molecular forces behind LLPS driven by added salts.
The focus of our project lies in the study of membrane-less cellular compartments formed through LLPS, with a particular emphasis on a well-defined biological system employed by the rabies virus to construct viral factories. This unique system exhibits reversible and reproducible phase separation, providing an excellent platform to explore the structure, colloidal forces, and factors influencing LLPS in biological systems.
Your primary responsibility will be the improvement of the light scattering setup combining turbidity, Rayleigh backscattering and multi-mode dynamic light scattering. Your expertise in light scattering techniques and diffusion wave spectroscopy (DWS) will be instrumental in unraveling the structural organization of proteins within the concentrated phase and mapping the response of the ATPS to variations in electrolyte type and concentration. We anticipate employing a range of advanced techniques, including X-ray, and neutron scattering, to gain valuable insights into the formation of LLPS using standard modelisation softwares. Complementary techniques are routine densimetryn, analytical utlra centrifugation and X-ray fluorescence to determine concentrations in coexisting phases.
To thrive in this role, you should possess a strong background in engineering, with a specialization in instrumentation, with a high motivation for biophysics, soft matter, or colloidal systems. Prior experience in employing light scattering techniques, and SAXS experiments would be highly advantageous.
This is an outstanding opportunity to contribute to groundbreaking research at the interface of viral biology and physical chemistry. If you possess an unwavering passion for instrumentation, we warmly invite you to join our team. At the end of this temporary contract, an opportunity for future industrial development, with an already identifed partner (SME) in Bordeaux, is foreseen.
As part of our transdisciplinary team, which combines expertise in viral biology and classical physical chemistry of colloids, you will collaborate closely with fellow researchers to decipher the underlying physicochemical principles that drive proteins to induce LLPS. Furthermore, your work will have a profound impact across various scientific areas, including fundamental biology, medical sciences, pharmacology, and drug design.

Desired profile

Holder of an engineering degree, you are autonomous and possess analytical skills and adaptability.

In accordance with CEA's commitments to the integration of people with disabilities, this position is open to everyone. The CEA offers accommodations and/or organizational arrangements for the inclusion of workers with disabilities.

About Cea Fr

Le CEA est un acteur majeur de la recherche, au service des citoyens, de l'économie et de l'Etat.

Il apporte des solutions concrètes à leurs besoins dans quatre domaines principaux : transition énergétique, transition numérique, technologies pour la médecine du futur, défense et sécurité sur un socle de recherche fondamentale. Le CEA s'engage depuis plus de 75 ans au service de la souveraineté scientifique, technologique et industrielle de la France et de l'Europe pour un présent et un avenir mieux maîtrisés et plus sûrs.

Implanté au coeur des territoires équipés de très grandes infrastructures de recherche, le CEA dispose d'un large éventail de partenaires académiques et industriels en France, en Europe et à l'international.

Les 20 000 collaboratrices et collaborateurs du CEA partagent trois valeurs fondamentales :

* La conscience des responsabilités
* La coopération
* La curiosité

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